Muller N, Lapicque F, Drelon E, Gillet P, Monot C, Poletto B, Netter P
URA CNRS 1288, Faculté de Médecine, Vandoeuvre les Nancy, France.
J Chromatogr. 1993 Jul 2;616(2):261-70. doi: 10.1016/0378-4347(93)80394-j.
Resolution of racemic tiaprofenic acid (TA) has been performed using immobilized human serum albumin as the stationary phase. The eluent was phosphate buffer-acetonitrile-n-octanoic acid (90:10:0.015, v/v). Detection was achieved at 305 nm. The pharmacokinetics of the enantiomers were studied following oral administration into humans and after subcutaneous injection in rats. Plasma concentrations of (+)-TA were much greater than those of (-)-TA. For the rat, the pharmacokinetic parameters between (-)-TA and (+)-TA were all statistically different (p < 0.005).
已使用固定化人血清白蛋白作为固定相拆分了消旋噻洛芬酸（TA）。洗脱液为磷酸盐缓冲液 - 乙腈 - 正辛酸（90:10:0.015，v/v）。在305nm处进行检测。对映体的药代动力学在人体口服给药和大鼠皮下注射后进行了研究。（+）-TA的血浆浓度远高于（-）-TA。对于大鼠，（-）-TA和（+）-TA之间的药代动力学参数均存在统计学差异（p < 0.005）。
