Skodras G, Wang J, Kragel P J
Department of Pathology, University of Missouri-Kansas City, Truman Medical Center.
Urology. 1993 Sep;42(3):338-42. doi: 10.1016/0090-4295(93)90629-o.
We report an uncommon case of primary prostatic signet-ring cell carcinoma which meets all criteria that define this clinicopathologic entity. Histologically, the tumor showed three different growth patterns, all of which contained large numbers of signet-ring cells. The predominant pattern, comprising approximately 50 percent of the tumor, was solid sheets of pure signet-ring cells. An intriguing finding was the presence of intestinal metaplasia involving the prostatic urethra and the large periurethral ducts. All mucin stains were intensely positive within the signet-ring cells and in the mucin lakes. Signet-ring cells stained positively for prostatic specific antigen, prostatic acid phosphatase, and carcinoembryonic antigen immunoperoxidase markers. Our patient presented with symptoms of urinary tract obstruction and locally widespread disease, infiltrating the rectum and the bladder, thus demonstrating the aggressive biologic behavior that traditionally has been ascribed to signet-ring cell carcinomas.
我们报告一例罕见的原发性前列腺印戒细胞癌，该病例符合定义这一临床病理实体的所有标准。组织学上，肿瘤呈现三种不同的生长模式，所有模式均包含大量印戒细胞。主要模式由纯印戒细胞的实性片块组成，约占肿瘤的50%。一个有趣的发现是前列腺尿道和大的尿道周围导管出现肠化生。在印戒细胞内和黏液湖中，所有黏液染色均呈强阳性。印戒细胞对前列腺特异性抗原、前列腺酸性磷酸酶和癌胚抗原免疫过氧化物酶标记物呈阳性染色。我们的患者表现为尿路梗阻症状和局部广泛病变，浸润直肠和膀胱，从而显示出传统上归因于印戒细胞癌的侵袭性生物学行为。
