Xiang M, Zhou L, Peng Y W, Eddy R L, Shows T B, Nathans J
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Neuron. 1993 Oct;11(4):689-701. doi: 10.1016/0896-6273(93)90079-7.
A search for POU domain transcription factors in human retina cDNA has led to the identification of Brn-3b, a class IV POU domain protein. Immunohistochemical experiments show that chicken, mouse, rabbit, monkey, and human retinas contain Brn-3b exclusively within a subpopulation of ganglion cells. In the adult mouse brain, Brn-3b is found only within cells in the deep layers of the superior colliculus, in the dorsal periaqueductal gray, and in a small cluster of cells in the brain stem near the area postrema. During the immediate postnatal period, cells containing Brn-3b are distributed in a number of regions within the brain stem and cerebellum. These data suggest that Brn-3b plays a role in determining and/or maintaining the identities of a small number of neurons, including a subset of visual system neurons.
对人类视网膜cDNA中的POU结构域转录因子进行搜索，已鉴定出Brn-3b，一种IV类POU结构域蛋白。免疫组织化学实验表明，鸡、小鼠、兔、猴和人类视网膜中的Brn-3b仅存在于神经节细胞亚群中。在成年小鼠大脑中，仅在上丘深层细胞、导水管周围灰质背侧以及靠近最后区的脑干中的一小群细胞中发现Brn-3b。在出生后即刻，含有Brn-3b的细胞分布在脑干和小脑的多个区域。这些数据表明，Brn-3b在确定和/或维持少数神经元的身份方面发挥作用，包括视觉系统神经元的一个子集。
