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[D-Arg1, D-Phe5, D-Trp7,9, Leu11] substance P inhibits the growth of human small cell lung cancer xenografts in vivo.

作者信息

Everard M J, Macaulay V M, Millar J L, Smith I E

机构信息

Section of Medicine, Royal Marsden Hospital, Belmont, Surrey, U.K.

出版信息

Eur J Cancer. 1993;29A(10):1450-3. doi: 10.1016/0959-8049(93)90019-c.

DOI:10.1016/0959-8049(93)90019-c
PMID:7691115
Abstract

We report the effect of substance P analogue, [D-Arg1, D-Phe5, D-Trp7,9, Leu11] substance P (D-Phe5SP), on the growth of human small cell lung cancer (SCLC) xenografts HC12 and ICR-SC112. Daily intraperitoneal (ip) administration (500 micrograms/day for 3 weeks) had no effect on HC12 growth rate. When administered by continuous 14-day subcutaneous (sc) infusion by osmotic minipump implanted adjacent to the tumour, D-Phe5SP 2.1 micrograms/day, caused significant inhibition (P < 0.05) of the growth of HC12 and ICR-SC112 on day 7 and day 14 compared with phosphate buffered saline (PBS)-treated controls. HC12 and ICR-SC112 tumour volume remained at 53-67% of control for 14-21 days postinfusion. D-Phe5SP 1 mg/day did not inhibit tumour growth, but dense fibrous capsules developed at the minipump outlet. Animals treated by sc infusion (but not ip) of PBS or D-Phe5SP failed to gain weight, and some groups lost weight. D-Phe5SP-treated animals had lower white blood counts than controls (not significant). These data suggest a potential clinical role for D-Phe5SP in the treatment of SCLC.

摘要

相似文献

1
[D-Arg1, D-Phe5, D-Trp7,9, Leu11] substance P inhibits the growth of human small cell lung cancer xenografts in vivo.
Eur J Cancer. 1993;29A(10):1450-3. doi: 10.1016/0959-8049(93)90019-c.
2
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Br J Cancer. 1992 Mar;65(3):388-92. doi: 10.1038/bjc.1992.78.
3
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[D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro.[D-精氨酸1，D-苯丙氨酸5，D-色氨酸7,9，亮氨酸11]P物质，一种在小鼠瑞士3T3细胞中有效的蛙皮素拮抗剂，可在体外抑制人小细胞肺癌细胞的生长。
Proc Natl Acad Sci U S A. 1988 Mar;85(6):1859-63. doi: 10.1073/pnas.85.6.1859.
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[D-Arg1, D-Phe5, D-Trp7,9, Leu11] substance P induces apoptosis in lung cancer cell lines in vitro.
Biochem Biophys Res Commun. 1994 Mar 30;199(3):1313-9. doi: 10.1006/bbrc.1994.1374.
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Broad spectrum neuropeptide antagonists inhibit the growth of small cell lung cancer in vivo.
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Stability and in vitro metabolism of the mitogenic neuropeptide antagonists [D-Arg1,D-Phe5, D-Trp7,9, Leu11]-substance P and [Arg6, D-Trp7,9, MePhe8]-substance P (6-11) characterized by high-performance liquid chromatography.通过高效液相色谱法对促有丝分裂神经肽拮抗剂[D-精氨酸1，D-苯丙氨酸5，D-色氨酸7,9，亮氨酸11]-P物质和[精氨酸6，D-色氨酸7,9，甲基苯丙氨酸8]-P物质（6-11）的稳定性及体外代谢进行了表征。
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Determination of two neuropeptide growth factor antagonists, [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-substance P and [Arg6,D-Trp7,9,N-MePhe8]- substance P(6-11), by high-performance liquid chromatography with electrochemical detection.
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Br J Cancer. 1994 Nov;70(5):886-92. doi: 10.1038/bjc.1994.415.

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Pharmaceutical development of a parenteral lyophilized formulation of the investigational antitumor neuropeptide antagonist [Arg6, D-Trp7,9, MePhe8]-Substance P [6-11].
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