Nehru B, Kaushal S
Department of Biophysics, Panjab University, Chandigarh, India.
Biol Trace Elem Res. 1993 Jul;38(1):27-34. doi: 10.1007/BF02783979.
An investigation on the influence of lead toxicity on some of the hepatic enzymes was studied in rats both after a shorter interval of 15 d and after longer intervals of 60 and 90 d. Three different doses of lead as 5, 10, and 50 mg/kg body wt were administered orally on every alternate day. Whereas significant inhibition of succinic dehydrogenase was seen following lead poisoning, the activity acid and alkaline phosphatase increased with lead intoxication. The histoarchitecture of the liver was grossly intact. Liver accumulated less lead compared to kidney at 60 and 90 d.
在大鼠中研究了铅毒性对某些肝酶的影响，观察期分别为较短的15天以及较长的60天和90天。每隔一天口服给予三种不同剂量的铅，分别为5、10和50毫克/千克体重。铅中毒后琥珀酸脱氢酶受到显著抑制，而酸性和碱性磷酸酶的活性则随铅中毒而增加。肝脏的组织结构大体完整。在60天和90天时，肝脏中积累的铅比肾脏少。
