Reuss-Borst M A, Pawelec G, Saal J G, Horny H P, Müller C A, Waller H D
Second Department of Internal Medicine, Medical University Clinic, Tübingen, Germany.
Br J Haematol. 1993 Jun;84(2):356-8. doi: 10.1111/j.1365-2141.1993.tb03083.x.
The clinical course of a 56-year-old female patient with Sweet's syndrome (SS) preceded by a myelodysplastic syndrome (MDS) is described. During the acute phase of the disease with high remittent fever, painful skin lesions and maximal leucocytosis IL-6 and G-CSF serum levels were extremely high, while TNF-alpha was only slightly elevated and gamma-interferon and IL1-beta were not increased. On clinical improvement IL-6 serum levels rapidly fell, whereas G-CSF values already slightly elevated before the manifestation of the disease slowly declined. High G-CSF levels triggered by a yet unknown factor could explain the leucocytosis, neutrophilic dermatosis and skin lesions in SS, while IL-6 probably induced the associated clinical symptoms of fever and pain.
本文描述了一名56岁女性患者，其患有先于骨髓增生异常综合征（MDS）的Sweet综合征（SS）的临床病程。在疾病急性期，患者出现高热、疼痛性皮肤病变及白细胞极度增多，此时血清白细胞介素-6（IL-6）和粒细胞集落刺激因子（G-CSF）水平极高，而肿瘤坏死因子-α（TNF-α）仅略有升高，γ-干扰素和白细胞介素-1β（IL1-β）未升高。随着临床症状改善，血清IL-6水平迅速下降，而在疾病表现之前就已略有升高的G-CSF值则缓慢下降。由未知因素引发的高G-CSF水平可能解释了SS中的白细胞增多、嗜中性皮病和皮肤病变，而IL-6可能诱发了发热和疼痛等相关临床症状。
