Ikeda M, Watanabe Y, Kitahara S, Inouye T
Department of Otolaryngology, National Defense Medical College, Saitama, Japan.
Int Arch Allergy Immunol. 1993;102(2):205-8. doi: 10.1159/000236574.
Lymphocyte subset abnormalities have been observed in a series of patients diagnosed with Wegener's granulomatosis (WG). Fifteen patients with WG were evaluated for lymphocyte subset abnormalities by two-color immunofluorescence flow cytometry. The WG group showed a decrease in CD4+ cells and an extraordinary increase in HLA-DR+ cells. The average percentages of HLA-DR+ cells of the normal group and WG group were 11.0 +/- 4.0 and 40.5 +/- 13.9% (CD3+HLA-DR+ = 20.3 + 9.4%). Within the CD8 family, CD8+57+, CD8+38+ and CD8+HLA-DR+ cells were markedly elevated. Our findings differ from other series which reported that the lymphocyte subsets in the peripheral blood of patients with WG were normal.
在一系列被诊断为韦格纳肉芽肿（WG）的患者中观察到淋巴细胞亚群异常。通过双色免疫荧光流式细胞术对15例WG患者的淋巴细胞亚群异常进行了评估。WG组显示CD4 +细胞减少，HLA - DR +细胞异常增加。正常组和WG组HLA - DR +细胞的平均百分比分别为11.0±4.0和40.5±13.9%（CD3 + HLA - DR + = 20.3 + 9.4%）。在CD8家族中，CD8 + 57 +、CD8 + 38 +和CD8 + HLA - DR +细胞明显升高。我们的研究结果与其他系列报道不同，其他报道称WG患者外周血中的淋巴细胞亚群是正常的。
