Kawakami J, Shimokawa M, Yamamoto K, Sawada Y, Asanuma A, Yanagisawa K, Iga T
Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, Japan.
Biol Pharm Bull. 1993 Jul;16(7):726-8. doi: 10.1248/bpb.16.726.
The convulsant interaction between enoxacin (ENX), a new quinolone antibacterial agent (NQ), and felbinac (FLB), a non-steroidal anti-inflammatory drug (NSAID), in vivo was reproduced as the change of GABA-induced current response in Xenopus oocytes injected with mouse brain mRNA. GABA (10 microM) response was inhibited by ENX in a dose-dependent manner, and IC50 of ENX was 96 microM. Moreover, the inhibitory effect of ENX was 80-fold potentiated in the presence of 10 microM FLB. The GABAA-antagonistic interaction between these two drugs in vitro was considered a possible mechanism of convulsant reaction after concomitant administration of NQs and NSAIDs in vivo.
