人γ球蛋白对平滑肌制剂的兴奋作用。

Stimulant effect of human gamma globulin on smooth muscle preparations.

作者信息

Abrahams Z, Chang S D, Sutter M C

机构信息

Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.

出版信息

Eur J Pharmacol. 1993 Jul 20;238(2-3):435-9. doi: 10.1016/0014-2999(93)90882-i.

DOI:10.1016/0014-2999(93)90882-i

PMID:7691625

Abstract

The effects of human gamma globulin on the contractile activity of spontaneously active rat mesenteric portal vein and guinea-pig taenia caeci and quiescent rat aorta and guinea-pig trachea muscles were studied in vitro. Human gamma globulin significantly increased the contractile activity of the spontaneously active muscles with respect to both amplitude and frequency of contraction whereas it had no significant effect on the contractile activity of quiescent muscle preparations. These findings suggest that immunoglobulins directly modulate smooth muscle including vasculature by modifying the membrane electrical activity associated with the generation of spontaneous activity.

摘要

在体外研究了人γ-球蛋白对自发活动的大鼠肠系膜门静脉、豚鼠盲肠带以及静态大鼠主动脉和豚鼠气管肌肉收缩活性的影响。人γ-球蛋白显著增加了自发活动肌肉的收缩活性，在收缩幅度和频率方面均如此，而对静态肌肉制剂的收缩活性没有显著影响。这些发现表明，免疫球蛋白通过改变与自发活动产生相关的膜电活动，直接调节包括脉管系统在内的平滑肌。