Sureda A, Valls A, Kadar E, Algara M, Inglés-Esteve J, Bigas A, Jaume M, Lacruz M, Tobajas L M, Rutllant M
Departament de Criobiologia i Teràpia Cellular, Hospital Duran i Reynals, Barcelona, Spain.
Exp Hematol. 1993 Nov;21(12):1605-7.
Granulocyte colony stimulating factor (G-CSF) stimulates the proliferation of progenitor cells committed to myeloid differentiation. In animal models, G-CSF is able to stimulate granulocyte recovery and promote survival after lethal or sublethal irradiation when administered as daily injections, suggesting an influence on the residual hematopoietic primitive precursors surviving irradiation. In this study, we clearly demonstrate that a single dose of G-CSF (1 mg/kg) administered to B6D2F1 mice 2 hours after a lethal dose 95/30 irradiation achieves a 78% survival at day +30 after irradiation. Survival of G-CSF treated mice compares favourably with that of syngenic bone marrow transplantation recipients (78% vs 90%, ns).
粒细胞集落刺激因子（G-CSF）可刺激致力于髓系分化的祖细胞增殖。在动物模型中，当每日注射给药时，G-CSF能够刺激粒细胞恢复，并促进致死性或亚致死性照射后的存活，这表明其对照射后存活的残余造血原始前体细胞有影响。在本研究中，我们清楚地证明，在给予致死剂量95/30照射后2小时给B6D2F1小鼠单次注射G-CSF（1 mg/kg），在照射后第30天的存活率达到78%。G-CSF治疗小鼠的存活率与同基因骨髓移植受者的存活率相比具有优势（78%对90%，无显著性差异）。
