单核细胞白血病CD1 +细胞上的S100蛋白和神经元特异性烯醇化酶，可能是朗格汉斯细胞的前体。
S100 protein and neuron-specific enolase on monocytic leukemic CD1+ cells, probable precursors of Langerhans cells.
作者信息
Misery L, Campos L, Sabido O, Kanitakis J, Dezutter-Dambuyant C, Guyotat D, Schmitt D
机构信息
INSERM U 346, Hôpital Edouard Herriot, Lyon, France.
出版信息
Eur J Haematol. 1993 Sep;51(3):132-5. doi: 10.1111/j.1600-0609.1993.tb00612.x.
Langerhans cells are characterized by specific markers, such as Birbeck granules and CD1a antigen. S100 protein and neuron-specific enolase are less specific but are expressed only on Langerhans cells among the cells of the phagocytic mononuclear system. In this study, the expression of these two antigens on many monocytic leukemic cells is shown. These cells could be precursors of Langerhans cells which have been transformed into malignant cells.
朗格汉斯细胞具有特定的标志物，如伯贝克颗粒和CD1a抗原。S100蛋白和神经元特异性烯醇化酶特异性较低，但在吞噬单核系统的细胞中仅在朗格汉斯细胞上表达。在本研究中，显示了这两种抗原在许多单核细胞白血病细胞上的表达。这些细胞可能是已转化为恶性细胞的朗格汉斯细胞的前体。
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