Ali A F
Department of Gynaecology and Obstetrics, Faculty of Medicine, Ain Shams University, Heliopolis, Cairo, Egypt.
Eur J Obstet Gynecol Reprod Biol. 1993 May;49(3):137-41. doi: 10.1016/0028-2243(93)90261-a.
Fifteen women with unruptured tubal pregnancies diagnosed by laparoscopy and ultrasound were treated with danazol 400 mg, injected directly into the affected tube. Study inclusion criteria were (i) a rising or plateauing level of serum beta human chorionic gonadotropin (hCG), (ii) a tubal swelling less than 3 x 3 cm, (iii) an intact tubal serosa and (iv) no active bleeding. The women were monitored with serial measurements of beta-hCG. All women responded to a single danazol injection, no treatment failures were observed. After 3 months, hysterosalpinography revealed tubal pateny on the involved side in 14 patients and in 1 patient the tube was blocked. Within 1 year after danazol therapy patients were attempting to or had conceived. Of these, there were 3 intrauterine pregnancies and 2 recurrent contralateral pregnancies.
通过腹腔镜检查和超声诊断为输卵管妊娠未破裂的15名女性，接受了400毫克达那唑直接注射到患侧输卵管的治疗。研究纳入标准为：（i）血清β-人绒毛膜促性腺激素（hCG）水平上升或稳定；（ii）输卵管肿胀小于3×3厘米；（iii）输卵管浆膜完整；（iv）无活动性出血。对这些女性进行β-hCG的系列测量监测。所有女性对单次达那唑注射均有反应，未观察到治疗失败情况。3个月后，子宫输卵管造影显示，14例患者患侧输卵管通畅，1例患者输卵管堵塞。达那唑治疗后1年内，患者尝试受孕或已受孕。其中，有3例宫内妊娠和2例对侧复发性妊娠。
