Rooney P, Kumar S
Department of Pathological Sciences, University of Manchester, UK.
Differentiation. 1993 Aug;54(1):1-9. doi: 10.1111/j.1432-0436.1993.tb00653.x.
The extracellular matrix plays a vital role in regulating normal tissue development and function--largely via the specific arrangement of macromolecules such as collagens, proteoglycans, glycosaminoglycans and glycoproteins. Previous reports have concentrated on associations between combinations of collagens/proteoglycans, collagens/glycoproteins and proteoglycans/glycosaminoglycans whilst little information is available on associations between collagens and free glycosaminoglycans. In this review, we discuss possible associations between collagens and the glycosaminoglycan hyaluronan; macromolecules which are known to exhibit changes in amount and composition during development and under pathological conditions. We demonstrate two types of collagen/hyaluronan association in vivo: the first, during the formation of extracellular matrix structures where neither collagens nor hyaluronan are degraded, resulting in the regulation of collagen fibrillogenesis, and the second, involving an inverse correlation between collagen synthesis and hyaluronan degradation and vice versa. We suggest that associations between collagens and hyaluronan play an important role in the initiation and maintenance of angiogenesis and put forward a model of cartilage vascularisation which relies on these associations.
细胞外基质在调节正常组织发育和功能方面发挥着至关重要的作用——主要是通过胶原蛋白、蛋白聚糖、糖胺聚糖和糖蛋白等大分子的特定排列来实现。以往的报道主要集中在胶原蛋白/蛋白聚糖、胶原蛋白/糖蛋白和蛋白聚糖/糖胺聚糖组合之间的关联，而关于胶原蛋白与游离糖胺聚糖之间关联的信息却很少。在这篇综述中，我们讨论了胶原蛋白与糖胺聚糖透明质酸之间可能存在的关联；已知这些大分子在发育过程中和病理条件下会在数量和组成上发生变化。我们在体内证明了两种胶原蛋白/透明质酸的关联：第一种，在细胞外基质结构形成过程中，胶原蛋白和透明质酸均未降解，从而调节胶原蛋白的原纤维形成；第二种，涉及胶原蛋白合成与透明质酸降解之间的负相关关系，反之亦然。我们认为，胶原蛋白与透明质酸之间的关联在血管生成的起始和维持中起着重要作用，并提出了一种依赖于这些关联的软骨血管化模型。
