Kawano N, Ohwada T, Yada K
Department of Neurosurgery, Kitasato University School of Medicine, Kanagawa.
Neurol Med Chir (Tokyo). 1993 Aug;33(8):543-6. doi: 10.2176/nmc.33.543.
Radical removal of craniopharyngiomas was attempted as the primary treatment in 12 adult and six child patients. No postoperative radiotherapy was given to patients undergoing total removal, while those undergoing subtotal removal received 50-60 Gy. Overall evaluation showed 15 cases of total removal and three of subtotal removal. One patient died of septicemia 2 months postoperatively and another developed a recurrent tumor which was removed totally at a second operation. The mean follow-up period was 7 years. The quality of life was "excellent" in 10 patients, "good" in five, and "fair" in two. Visual losses were minimized and endocrinological disturbances treated medically. These satisfactory results indicate that radical surgical removal is the first choice for treatment of craniopharyngioma irrespective of the age of patients.
12例成年患者和6例儿童患者尝试将颅咽管瘤根治性切除作为主要治疗方法。接受全切的患者未进行术后放疗,而接受次全切的患者接受了50 - 60 Gy的放疗。总体评估显示15例全切,3例次全切。1例患者术后2个月死于败血症,另1例出现复发性肿瘤,在第二次手术时被完全切除。平均随访期为7年。10例患者生活质量“优秀”,5例“良好”,2例“一般”。视力损失降至最低,内分泌紊乱采用药物治疗。这些令人满意的结果表明,无论患者年龄如何,根治性手术切除都是颅咽管瘤治疗的首选方法。