Appenrodt E, Pharow L, Brattström A
Institut of Physiology, Magdeburg School of Medicine, FRG.
Neuropeptides. 1993 Jul;25(1):77-81. doi: 10.1016/0143-4179(93)90073-j.
The effects of intracerebroventricularly (i.c.v.) administered Substance P (100 pg, 1 microgram, 10 micrograms) on mean blood pressure (MBP), inter-beat interval (IBI) and the baroreceptor heart reflex (BHR) were studied in conscious Wistar rats. The BHR was induced by intravenous injection of both phenylephrine (1 microgram) and sodium nitroprusside (5 micrograms) before and after SP administration (3 and 15 min). The dose of 100 pg SP was without effect on the resting values of both MBP and IBI but enhanced the BHR sensitivity by about + 0.5 ms/mm Hg in the phenylephrine test 3 min after i.c.v. SP. 1 microgram and 10 micrograms SP caused a long-lasting dose dependent increase in MBP and changed the IBI. In contrast to the results obtained with 100 pg, the BHR sensitivity was impaired-1 microgram SP: -0.2 ms/mm Hg (phenylephrine) and -0.45 ms/mm Hg (nitroprusside), 10 micrograms SP: -0.35 ms/mm Hg (phenylephrine). These changes in BHR sensitivity were only recognised 3 min, but not 15 min, after i.c.v. treatment even hough changes in the resting values of MBP and IBI were still present at 15 min. These data suggest that SP through the cerebrospinal fluid may participate in central cardiovascular control and, moreover, it may influence the baroreflex regulation.
研究了向清醒的Wistar大鼠脑室内注射P物质（100皮克、1微克、10微克）对平均血压（MBP）、心跳间期（IBI）和压力感受器心脏反射（BHR）的影响。在注射P物质前及注射后3分钟和15分钟，通过静脉注射去氧肾上腺素（1微克）和硝普钠（5微克）诱导BHR。100皮克P物质剂量对MBP和IBI的静息值无影响，但在脑室内注射P物质3分钟后的去氧肾上腺素试验中，可使BHR敏感性提高约+0.5毫秒/毫米汞柱。1微克和10微克P物质可导致MBP出现持久的剂量依赖性升高，并改变IBI。与100皮克的结果相反，BHR敏感性受损——1微克P物质：-0.2毫秒/毫米汞柱（去氧肾上腺素）和-0.45毫秒/毫米汞柱（硝普钠），10微克P物质：-0.35毫秒/毫米汞柱（去氧肾上腺素）。即使在15分钟时MBP和IBI的静息值仍有变化，但这些BHR敏感性变化仅在脑室内注射治疗后3分钟被识别，而在15分钟时未被识别。这些数据表明，P物质可能通过脑脊液参与中枢心血管控制，而且可能影响压力反射调节。
