新型二肽P物质拮抗剂FK888的设计 - Suppr | 超能文献

Design of a novel dipeptide substance P antagonist FK888.

作者信息

Hagiwara D, Miyake H, Igari N, Murano K, Morimoto H, Murai M, Fujii T, Matsuo M

机构信息

Department of Chemistry, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.

出版信息

Regul Pept. 1993 Jul 2;46(1-2):332-4. doi: 10.1016/0167-0115(93)90076-k.

DOI:10.1016/0167-0115(93)90076-k

Abstract

摘要

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。

相似文献

1

Design of a novel dipeptide substance P antagonist FK888.新型二肽P物质拮抗剂FK888的设计

Regul Pept. 1993 Jul 2;46(1-2):332-4. doi: 10.1016/0167-0115(93)90076-k.

2

The pharmacological properties of FK888, a novel dipeptide NK1 antagonist.新型二肽NK1拮抗剂FK888的药理学特性。

Regul Pept. 1993 Jul 2;46(1-2):335-7. doi: 10.1016/0167-0115(93)90077-l.

3

Correlation between binding characteristics and functional antagonism in human glioma cells by tachykinin NK1 receptor antagonists.速激肽NK1受体拮抗剂对人胶质瘤细胞结合特性与功能拮抗作用之间的相关性

Eur J Pharmacol. 1999 Jun 25;374(3):435-43. doi: 10.1016/s0014-2999(99)00334-9.

4

Studies on neurokinin antagonists. 4. Synthesis and structure-activity relationships of novel dipeptide substance P antagonists: N2-[(4R)-4-hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl]-N- methyl-N-(phenylmethyl)-3-(2-naphthyl)-L-alaninamide and its related compounds.神经激肽拮抗剂的研究。4. 新型二肽P物质拮抗剂的合成及构效关系：N2-[(4R)-4-羟基-1-[(1-甲基-1H-吲哚-3-基)羰基]-L-脯氨酰]-N-甲基-N-(苯甲基)-3-(2-萘基)-L-丙氨酰胺及其相关化合物

J Med Chem. 1994 Jun 24;37(13):2090-9. doi: 10.1021/jm00039a022.

5

Conserved HisVI-17 of the NK-1 receptor is involved in binding of non-peptide antagonists but not substance P.

FEBS Lett. 1993 Dec 28;336(3):506-10. doi: 10.1016/0014-5793(93)80865-r.

6

Effects of two novel tachykinin antagonists, FK224 and FK888, on neurogenic airway plasma exudation, bronchoconstriction and systemic hypotension in guinea-pigs in vivo.两种新型速激肽拮抗剂FK224和FK888对豚鼠体内神经源性气道血浆渗出、支气管收缩和全身性低血压的影响

Br J Pharmacol. 1993 Mar;108(3):844-51. doi: 10.1111/j.1476-5381.1993.tb12888.x.

7

A flexible approach to the design of new potent substance P receptor ligands.一种设计新型强效P物质受体配体的灵活方法。

J Pharm Pharmacol. 2001 Jul;53(7):929-34. doi: 10.1211/0022357011776324.

8

Effects of an NK1 receptor antagonist, FK888, on constriction and plasma extravasation induced in guinea pig airway by neurokinins and capsaicin.NK1受体拮抗剂FK888对神经激肽和辣椒素诱导的豚鼠气道收缩及血浆外渗的影响。

Eur J Pharmacol. 1993 May 12;236(1):7-13. doi: 10.1016/0014-2999(93)90220-c.

9

Variations in affinities for the NK1 receptor: differences between the non-peptide substance P antagonists RP 67580 and CP-96,345 and the agonist septide.对NK1受体亲和力的差异：非肽类P物质拮抗剂RP 67580和CP-96,345与激动剂septide之间的差异。

Regul Pept. 1993 Jul 2;46(1-2):300-3. doi: 10.1016/0167-0115(93)90066-h.

10

[Discovery and pharmacological properties of selective neurokinin-receptor antagonists, FK224 and FK888].[选择性神经激肽受体拮抗剂FK224和FK888的发现及其药理特性]

Nihon Yakurigaku Zasshi. 1995 Sep;106(3):193-204. doi: 10.1254/fpj.106.193.