Sattel H, Geiger-Kabisch C, Schreiter-Gasser U, Besthorn C, Förstl H
Zentralinstitut für Seelische Gesundheit, Sonderforschungsbereich 258, Mannheim.
Z Gerontol. 1993 Jul-Aug;26(4):275-9.
A semi-structured interview was administered to the closest relatives of 50 patients with presenile or senile dementia of the Alzheimer type. The disturbances most frequently reported were: wandering/pacing (56%, cumulative percentage), aggressive behavior (44%) and - significantly related to more severe stages of dementia - apathy/loss of drive (58%), eating disturbances (46%) and disturbances of the sleep-waking cycle (32%). Depressive symptoms were observed in 58% of the patients, preferentially in the early stages of illness with preserved insight. Signs of paranoid delusions (46%), delusional misidentification (34%), visual (32%) and auditory hallucinations (16%) were encountered temporarily in a large number of patients. The importance of "non-cognitive" symptoms in Alzheimer's disease is underlined by their subjective significance for the caregivers.
对50例早老性或老年性阿尔茨海默型痴呆患者的近亲进行了半结构式访谈。最常报告的障碍有：徘徊/踱步（56%，累积百分比）、攻击行为（44%），以及与更严重痴呆阶段显著相关的冷漠/动力丧失（58%）、进食障碍（46%）和睡眠-觉醒周期紊乱（32%）。58%的患者观察到抑郁症状，在疾病早期且自知力保留时更为常见。大量患者曾暂时出现偏执妄想（46%）、妄想性身份识别障碍（34%）、视觉幻觉（32%）和听觉幻觉（16%）。“非认知”症状对照顾者具有主观重要性，这凸显了其在阿尔茨海默病中的重要性。
