Wiedermann F J, Kähler C M, Reinisch N, Wiedermann C J
Department of Internal Medicine, Faculty of Medicine, University of Innsbruck, Austria.
Acta Haematol. 1993;89(4):213-5. doi: 10.1159/000204527.
To investigate the role of tachykinins in allergic inflammation, the effect of substance P (SP) on normal human eosinophil migration was examined in Boyden chamber type assays. SP stimulated eosinophil migration in vitro with an EC50 of about 1-10 pM and maximal effects were seen at 100 pM. A carboxy-terminal fragment of SP possessed appreciable activity whereas an amino-terminal fragment was inactive. Data represented in this paper and previous studies suggest that eosinophils are attracted by SP and activated to enhanced mediator release and cytotoxic activity.
