Insulin-like growth factor-I and binding protein-1 can modulate fetal brain cell growth during maternal starvation.
作者信息
Shambaugh G, Glick R, Radosevich J, Unterman T
机构信息
Medical Research Service, VA Lakeside Medical Center, Chicago, Illinois.
出版信息
Ann N Y Acad Sci. 1993 Aug 27;692:270-2. doi: 10.1111/j.1749-6632.1993.tb26231.x.
Abstract
- Stimulation of brain cell growth by fetal plasma is reduced when levels of IGF-I are low and IGFBP-1 are high. 2. Fetal brain cells respond to IGFs in cell culture, and effects of plasma are reduced by addition of IGFBP-1. 3. Increased levels of IGFBP-1 and reduced availability of IGF-I may contribute to reduced brain growth when maternal nutrition is impaired.
摘要
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