Gerl A, Clemm C, Hentrich M, Hartenstein R, Wilmanns W
Medizinische Klinik III, Klinikum Grosshadern, Ludwig-Maximilians-Universität München, Germany.
Acta Oncol. 1993;32(5):541-6. doi: 10.3109/02841869309096115.
Sixty-one patients with advanced metastatic non-seminomatous germ cell tumors were treated with etoposide 120 mg/m2, cisplatin 30 mg/m2, bleomycin 12 mg/m2, and cyclophosphamide 300 mg/m2 daily for four days; and additional bleomycin bolus injection of 15 mg was given on day 1. Fifty patients (82%) were treated with four to six courses at 3-week intervals. Forty patients (66%) attained complete remission, and further 7 patients (11%) achieved a marker-negative partial remission accounting for a favorable response rate of 77%. Hematologic toxicity was considerable and there were two treatment-related deaths. After a median observation time of 47 months (range 12 to 108 months), 43 patients were alive, of which 38 had continuous complete remission, one a second complete remission, two marker-negative stable disease and two progressive disease. Our results are similar to those reported by other investigators for poor-risk metastatic non-seminomatous germ cell tumors treated with dose-intensified regimens.
61例晚期转移性非精原细胞瘤性生殖细胞肿瘤患者接受如下治疗：依托泊苷120mg/m²、顺铂30mg/m²、博来霉素12mg/m²及环磷酰胺300mg/m²，每日一次，共四天；第1天额外给予博来霉素15mg推注。50例患者（82%）每3周接受4至6个疗程的治疗。40例患者（66%）达到完全缓解，另有7例患者（11%）实现肿瘤标志物阴性的部分缓解，总有效率为77%。血液学毒性较为严重，有2例与治疗相关的死亡病例。经过中位47个月（范围12至108个月）的观察期后，43例患者存活，其中38例持续完全缓解，1例再次完全缓解，2例肿瘤标志物阴性病情稳定，2例疾病进展。我们的结果与其他研究者报道的采用剂量强化方案治疗的高危转移性非精原细胞瘤性生殖细胞肿瘤的结果相似。
