Takaku F
National Medical Center, Tokyo, Japan.
Hum Cell. 1993 Jun;6(2):75-81.
Clinical usefulness of cytokines in cancer treatment has been described. Cytokines presently used in clinical practice are IFNs, IL-2, and hematopoietic growth factors. IFNs and IL-2 used with an expectation of direct antitumor effect of these cytokines have been proven to be specifically effective against certain types of tumors. Hematopoietic growth factors have been used as the adjuvant drugs in cancer treatment and proven to be effective against neutropenia and associated infections after chemotherapy and bone marrow transplantation. Future development of new cytokines and trials on the combination among cytokines and cytokines with chemotherapeutic agents, will promote the usefulness of cytokines in cancer treatment.
细胞因子在癌症治疗中的临床应用已得到描述。目前临床实践中使用的细胞因子有干扰素、白细胞介素-2和造血生长因子。使用干扰素和白细胞介素-2期望这些细胞因子具有直接抗肿瘤作用，已被证明对某些类型的肿瘤具有特异性疗效。造血生长因子已被用作癌症治疗的辅助药物，并被证明对化疗和骨髓移植后的中性粒细胞减少及相关感染有效。新细胞因子的未来发展以及细胞因子之间、细胞因子与化疗药物联合使用的试验，将提高细胞因子在癌症治疗中的应用价值。
