通道噪声对轴突分支处差异传导影响的模拟研究
Simulation study on effects of channel noise on differential conduction at an axon branch.
作者信息
Horikawa Y
机构信息
Information and Computer Science Laboratory, Faculty of Education, Kagawa University, Takamatsu, Japan.
出版信息
Biophys J. 1993 Aug;65(2):680-6. doi: 10.1016/S0006-3495(93)81096-8.
Abstract
Effects of membrane channel noise (random opening and closing of ion channels) are studied on spike conduction at a branching point on an axon. Computer simulation is done on the basis of a stochastic version of the Hodgkin-Huxley cable model, into which the channel noise is incorporated. It is shown that the channel noise makes conduction of spikes into daughter branches random; spikes randomly succeed or fail in conduction into daughter branches. The conduction is then randomly differential even though the forms and properties of daughter branches are the same. The randomness is considerable when the radius of an axon is small (approximately 1 microns).
摘要
研究了膜通道噪声（离子通道的随机开放和关闭）对轴突分支点处动作电位传导的影响。基于霍奇金-赫胥黎电缆模型的随机版本进行计算机模拟，并将通道噪声纳入其中。结果表明，通道噪声使动作电位向分支传导具有随机性；动作电位向分支传导时随机成功或失败。即使分支的形态和特性相同，传导也会随机出现差异。当轴突半径较小时（约1微米），随机性相当显著。
相似文献
1
Simulation study on effects of channel noise on differential conduction at an axon branch.通道噪声对轴突分支处差异传导影响的模拟研究
Biophys J. 1993 Aug;65(2):680-6. doi: 10.1016/S0006-3495(93)81096-8.
2
Spiking synchronization of ion channel clusters on an axon.轴突上离子通道簇的尖峰同步。
Phys Rev E Stat Nonlin Soft Matter Phys. 2007 Jul;76(1 Pt 1):011905. doi: 10.1103/PhysRevE.76.011905. Epub 2007 Jul 11.
3
Stochastic simulations on the reliability of action potential propagation in thin axons.细轴突中动作电位传播可靠性的随机模拟。
PLoS Comput Biol. 2007 May;3(5):e79. doi: 10.1371/journal.pcbi.0030079.
4
Analysis of the optimal channel density of the squid giant axon using a reparameterized Hodgkin-Huxley model.使用重新参数化的霍奇金-赫胥黎模型分析鱿鱼巨轴突的最佳通道密度
J Neurophysiol. 2006 Aug;96(2):959; author reply 960. doi: 10.1152/jn.00331.2006.
5
A mathematical model for conduction of action potentials along bifurcating axons.沿分支轴突传导动作电位的数学模型。
J Physiol. 1979 Oct;295:323-43. doi: 10.1113/jphysiol.1979.sp012971.
6
Capacitance fluctuations causing channel noise reduction in stochastic Hodgkin-Huxley systems.随机霍奇金 - 赫胥黎系统中引起通道噪声降低的电容波动。
Phys Biol. 2006 Nov 22;3(4):248-54. doi: 10.1088/1478-3975/3/4/002.
7
Firing behaviour in stochastic nerve membrane models with different pore densities.具有不同孔隙密度的随机神经膜模型中的放电行为。
Acta Physiol Scand. 1980 Jan;108(1):49-60. doi: 10.1111/j.1748-1716.1980.tb06499.x.
8
Channel-based Langevin approach for the stochastic Hodgkin-Huxley neuron.用于随机霍奇金-赫胥黎神经元的基于通道的朗之万方法。
Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Jan;87(1):012716. doi: 10.1103/PhysRevE.87.012716. Epub 2013 Jan 22.
9
Intrinsic coherence resonance in excitable membrane patches.可兴奋膜片内的固有相干共振。
Math Biosci. 2007 Jun;207(2):235-45. doi: 10.1016/j.mbs.2006.08.024. Epub 2006 Sep 7.
10
Stochastic differential equation models for ion channel noise in Hodgkin-Huxley neurons.霍奇金 - 赫胥黎神经元中离子通道噪声的随机微分方程模型。
Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Apr;83(4 Pt 1):041908. doi: 10.1103/PhysRevE.83.041908. Epub 2011 Apr 11.
引用本文的文献
1
Branching morphology determines signal propagation dynamics in neurons.分支形态决定神经元中信号的传播动态。
Sci Rep. 2017 Aug 21;7(1):8877. doi: 10.1038/s41598-017-09184-3.
2
Spike propagation in dendrites with stochastic ion channels.具有随机离子通道的树突中的锋电位传播。
J Comput Neurosci. 2006 Feb;20(1):77-84. doi: 10.1007/s10870-006-4770-0. Epub 2006 Feb 20.
3
Subthreshold voltage noise due to channel fluctuations in active neuronal membranes.有源神经元膜中通道波动引起的亚阈值电压噪声。
J Comput Neurosci. 2000 Sep-Oct;9(2):133-48. doi: 10.1023/a:1008967807741.
本文引用的文献
1
A quantitative description of membrane current and its application to conduction and excitation in nerve.膜电流的定量描述及其在神经传导和兴奋中的应用。
J Physiol. 1952 Aug;117(4):500-44. doi: 10.1113/jphysiol.1952.sp004764.
2
Firing behaviour in nerve cell models with a two-state pore system.具有双态孔系统的神经细胞模型中的放电行为。
Acta Physiol Scand. 1980 Aug;109(4):377-92. doi: 10.1111/j.1748-1716.1980.tb06610.x.
3
Modeling repetitive firing and bursting in a small unmyelinated nerve fiber.模拟小型无髓神经纤维中的重复放电和爆发式放电。
Biophys J. 1981 Sep;35(3):715-30. doi: 10.1016/S0006-3495(81)84823-0.
4
Modulation of impulse conduction along the axonal tree.沿轴突树突对冲动传导的调节。
Annu Rev Biophys Bioeng. 1980;9:143-79. doi: 10.1146/annurev.bb.09.060180.001043.
5
Relationship between membrane excitability and single channel open-close kinetics.膜兴奋性与单通道开闭动力学之间的关系。
Biophys J. 1983 May;42(2):151-7. doi: 10.1016/S0006-3495(83)84381-1.
6
Digital computer solutions for excitation and propagation of the nerve impulse.用于神经冲动激发与传播的数字计算机解决方案。
Biophys J. 1966 Sep;6(5):583-99. doi: 10.1016/S0006-3495(66)86679-1.
7
Multiple meaning in single visual units.单一视觉单元中的多重含义。
Brain Behav Evol. 1970;3(1):72-101. doi: 10.1159/000125464.
8
Changes of action potential shape and velocity for changing core conductor geometry.改变核心导体几何形状时动作电位形状和速度的变化。
Biophys J. 1974 Oct;14(10):731-57. doi: 10.1016/S0006-3495(74)85947-3.
9
The effect of membrane parameters on the properties of the nerve impulse.膜参数对神经冲动特性的影响。
Biophys J. 1972 Sep;12(9):1132-44. doi: 10.1016/S0006-3495(72)86150-2.
10
Differential conduction at axonal bifurcations. II. Theoretical basis.轴突分支处的差异传导。II. 理论基础。
J Neurophysiol. 1988 Apr;59(4):1286-95. doi: 10.1152/jn.1988.59.4.1286.
Zotero 插件