Uematsu Y, Komai N, Hirano A, Shimizu M, Tanaka Y, Naka D, Yukawa S, Itakura T, Hayashi S
Department of Neurological Surgery, Wakayama Medical College.
Noshuyo Byori. 1993;10(1):43-52.
A variety of epithelial cysts in the central nervous system were examined immunohistochemically for expression of cytokeratins. Colloid cysts, Rathke's cleft cysts and epithelial cysts in the spinal canal expressed complex type cytokeratins, while enterogenous cysts and neuroectodermal cysts showed only simple type cytokeratins. Colloid cysts showed a pattern of cytokeratins similar to that of upper respiratory tract which is endodermal in origin. In contrast, Rathke's cleft cysts showed a pattern of cytokeratins similar to that of the adenohypophysis and salivary gland which are ectodermal in origin. The CK immunohistochemical studies are discussed with regards to diagnostic significance and origins of their cysts.
对中枢神经系统中的多种上皮囊肿进行免疫组织化学检查，以检测细胞角蛋白的表达。松果体囊肿、拉克氏裂囊肿和椎管内上皮囊肿表达复合型细胞角蛋白，而肠源性囊肿和神经外胚层囊肿仅显示单纯型细胞角蛋白。松果体囊肿显示出与起源于内胚层的上呼吸道相似的细胞角蛋白模式。相比之下，拉克氏裂囊肿显示出与起源于外胚层的腺垂体和唾液腺相似的细胞角蛋白模式。本文讨论了细胞角蛋白免疫组织化学研究在囊肿诊断意义和起源方面的应用。
