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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Hsu K S, Fu W M, Lin-Shiau S Y

Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei.

Br J Pharmacol. 1993 Sep;110(1):163-8. doi: 10.1111/j.1476-5381.1993.tb13787.x.

The effects of 2,2',2''-tripyridine on the nicotinic acetylcholine (ACh) receptor channels were studied in the cultured myocytes of 1-day-old Xenopus embryos. 2. 2,2',2''-Tripyridine depressed the amplitude of iontophoretic ACh-induced current at a low frequency of 0.7 Hz stimulation and it not only decreased the initial responses but also enhanced the run-down of ACh-induced current at higher frequency stimulation of 7 Hz and 30 Hz. 3. Single ACh channel recordings showed that 2,2',2''-tripyridine decreased the channel conductance, the opening frequency and mean open time of both types of low- and high-conductance channels. 4. These results suggest that the blocking actions of 2,2',2''-tripyridine on ACh receptor channels in the skeletal muscle may contribute to the depression of the nerve-evoked contraction of the mouse diaphragm as reported previously.

在1日龄非洲爪蟾胚胎的培养肌细胞中研究了2,2',2''-三联吡啶对烟碱型乙酰胆碱（ACh）受体通道的影响。2. 2,2',2''-三联吡啶在0.7 Hz的低频刺激下降低了离子电泳ACh诱导电流的幅度，它不仅降低了初始反应，还在7 Hz和30 Hz的高频刺激下增强了ACh诱导电流的衰减。3. 单通道ACh记录显示，2,2',2''-三联吡啶降低了低电导和高电导两种类型通道的通道电导、开放频率和平均开放时间。4. 这些结果表明，如先前报道，2,2',2''-三联吡啶对骨骼肌中ACh受体通道的阻断作用可能导致小鼠膈肌神经诱发收缩的抑制。

Hsu K S, Fu W M, Lin-Shiau S Y

Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei.

Br J Pharmacol. 1993 Sep;110(1):163-8. doi: 10.1111/j.1476-5381.1993.tb13787.x.

The effects of 2,2',2''-tripyridine on the nicotinic acetylcholine (ACh) receptor channels were studied in the cultured myocytes of 1-day-old Xenopus embryos. 2. 2,2',2''-Tripyridine depressed the amplitude of iontophoretic ACh-induced current at a low frequency of 0.7 Hz stimulation and it not only decreased the initial responses but also enhanced the run-down of ACh-induced current at higher frequency stimulation of 7 Hz and 30 Hz. 3. Single ACh channel recordings showed that 2,2',2''-tripyridine decreased the channel conductance, the opening frequency and mean open time of both types of low- and high-conductance channels. 4. These results suggest that the blocking actions of 2,2',2''-tripyridine on ACh receptor channels in the skeletal muscle may contribute to the depression of the nerve-evoked contraction of the mouse diaphragm as reported previously.

在1日龄非洲爪蟾胚胎的培养肌细胞中研究了2,2',2''-三联吡啶对烟碱型乙酰胆碱（ACh）受体通道的影响。2. 2,2',2''-三联吡啶在0.7 Hz的低频刺激下降低了离子电泳ACh诱导电流的幅度，它不仅降低了初始反应，还在7 Hz和30 Hz的高频刺激下增强了ACh诱导电流的衰减。3. 单通道ACh记录显示，2,2',2''-三联吡啶降低了低电导和高电导两种类型通道的通道电导、开放频率和平均开放时间。4. 这些结果表明，如先前报道，2,2',2''-三联吡啶对骨骼肌中ACh受体通道的阻断作用可能导致小鼠膈肌神经诱发收缩的抑制。