2,2',2''-三联吡啶对非洲爪蟾胚胎肌肉细胞中烟碱型乙酰胆碱受体通道的阻断作用。
Blockade by 2,2',2''-tripyridine of the nicotinic acetylcholine receptor channels in embryonic Xenopus muscle cells.
作者信息
Hsu K S, Fu W M, Lin-Shiau S Y
机构信息
Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei.
出版信息
Br J Pharmacol. 1993 Sep;110(1):163-8. doi: 10.1111/j.1476-5381.1993.tb13787.x.
Abstract
- The effects of 2,2',2''-tripyridine on the nicotinic acetylcholine (ACh) receptor channels were studied in the cultured myocytes of 1-day-old Xenopus embryos. 2. 2,2',2''-Tripyridine depressed the amplitude of iontophoretic ACh-induced current at a low frequency of 0.7 Hz stimulation and it not only decreased the initial responses but also enhanced the run-down of ACh-induced current at higher frequency stimulation of 7 Hz and 30 Hz. 3. Single ACh channel recordings showed that 2,2',2''-tripyridine decreased the channel conductance, the opening frequency and mean open time of both types of low- and high-conductance channels. 4. These results suggest that the blocking actions of 2,2',2''-tripyridine on ACh receptor channels in the skeletal muscle may contribute to the depression of the nerve-evoked contraction of the mouse diaphragm as reported previously.
摘要
- 在1日龄非洲爪蟾胚胎的培养肌细胞中研究了2,2',2''-三联吡啶对烟碱型乙酰胆碱（ACh）受体通道的影响。2. 2,2',2''-三联吡啶在0.7 Hz的低频刺激下降低了离子电泳ACh诱导电流的幅度，它不仅降低了初始反应，还在7 Hz和30 Hz的高频刺激下增强了ACh诱导电流的衰减。3. 单通道ACh记录显示，2,2',2''-三联吡啶降低了低电导和高电导两种类型通道的通道电导、开放频率和平均开放时间。4. 这些结果表明，如先前报道，2,2',2''-三联吡啶对骨骼肌中ACh受体通道的阻断作用可能导致小鼠膈肌神经诱发收缩的抑制。
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