毒蕈碱激动剂对大鼠松果体细胞中环鸟苷酸（cGMP）的形成没有可测量的影响。

Muscarinic agonists have no measurable effect on cGMP formation of rat pinealocytes.

作者信息

Spessert R, Vollrath L

机构信息

Department of Anatomy, Johannes Gutenberg University, Mainz, Germany.

出版信息

Brain Res Bull. 1993;32(6):589-92. doi: 10.1016/0361-9230(93)90159-9.

DOI:10.1016/0361-9230(93)90159-9

PMID:7693307

Abstract

Previous studies have shown that muscarinic agonists stimulate cGMP formation in various tissues including rat brain. As in the pineal gland cGMP formation varies considerably under various experimental conditions, in the present investigation the effects of muscarinic agonists were tested. Muscarinic agonists neither stimulated pineal cGMP formation nor affected cGMP accumulation, resulting from administration of phosphodiesterase (PDE) inhibitors, norepinephrine (NE), or sodium nitroprusside (SNP). Because muscarinic agonists are known to stimulate pineal inositol phosphate (Ip) formation we suspect that muscarine-related Ip formation does not affect cGMP formation in rat pineal gland.

摘要

先前的研究表明，毒蕈碱激动剂可刺激包括大鼠脑在内的多种组织中cGMP的生成。由于在松果体中，cGMP的生成在各种实验条件下差异很大，因此在本研究中对毒蕈碱激动剂的作用进行了测试。毒蕈碱激动剂既不刺激松果体cGMP的生成，也不影响磷酸二酯酶（PDE）抑制剂、去甲肾上腺素（NE）或硝普钠（SNP）给药后cGMP的积累。因为已知毒蕈碱激动剂可刺激松果体肌醇磷酸（Ip）的生成，所以我们推测与毒蕈碱相关的Ip生成不会影响大鼠松果体中cGMP的生成。