新生儿脐带血清α2-巨球蛋白与出生时胎儿大小

Neonatal cord serum alpha 2-macroglobulin and fetal size at birth.

作者信息

Cliver S P, Goldenberg R L, Neel N R, Tamura T, Johnston K E, Hoffman H J

机构信息

Department of Obstetrics & Gynecology, University of Alabama at Birmingham 35233-7333.

出版信息

Early Hum Dev. 1993 Jul;33(3):201-6. doi: 10.1016/0378-3782(93)90146-l.

DOI:10.1016/0378-3782(93)90146-l

PMID:7693436

Abstract

Serum concentrations of alpha-2-macroglobulin (alpha 2M) were measured in cord blood from neonates born in Alabama, USA and in Guatemala. Results indicate an inverse relationship between cord serum alpha 2M concentrations and birth weight of newborns in both locations. Infants with lower birth weight had higher cord serum alpha 2M concentrations as compared to those with higher birth weight. The results of the present study using cord serum are similar to those in our previous reports indicating an inverse relationship between maternal serum alpha 2M concentrations and birth weight. This distinctive and reproducible association between alpha 2M concentrations and fetal size in maternal as well as cord blood samples warrants further investigations to determine the mechanism of this relationship.

摘要

在美国阿拉巴马州和危地马拉出生的新生儿脐带血中，检测了α-2-巨球蛋白（α2M）的血清浓度。结果表明，在这两个地区，脐带血清α2M浓度与新生儿出生体重呈负相关。与出生体重较高的婴儿相比，出生体重较低的婴儿脐带血清α2M浓度更高。本研究使用脐带血清的结果与我们之前的报告相似，表明母体血清α2M浓度与出生体重呈负相关。母体和脐带血样本中α2M浓度与胎儿大小之间这种独特且可重复的关联值得进一步研究，以确定这种关系的机制。