Wiley A S, Lubree H G, Joshi S M, Bhat D S, Ramdas L V, Rao A S, Thuse N V, Deshpande V U, Yajnik C S
Anthropology Department and Human Biology Program, Indiana University, Bloomington, IN, USA.
Kamalanayan Bajaj Diabetology Research Centre, KEM Hospital Research Centre, KEM Hospital, Pune, Maharashtra, India.
Pediatr Obes. 2016 Apr;11(2):151-7. doi: 10.1111/ijpo.12038. Epub 2015 May 8.
Indian newborns have been described as 'thin-fat' compared with European babies, but little is known about how this phenotype relates to the foetal growth factor IGF-I (insulin-like growth factor I) or its binding protein IGFBP-3.
To assess cord IGF-I and IGFBP-3 concentrations in a sample of Indian newborns and evaluate their associations with neonatal adiposity and maternal factors.
A prospective cohort study of 146 pregnant mothers with dietary, anthropometric and biochemical measurements at 28 and 34 weeks gestation. Neonatal weight, length, skin-folds, circumferences, and cord blood IGF-I and IGFBP-3 concentrations were measured at birth.
Average cord IGF-I and IGFBP-3 concentrations were 46.6 (2.2) and 1269.4 (41) ng mL(-1) , respectively. Girls had higher mean IGF-I than boys (51.4 ng mL(-1) vs. 42.9 ng mL(-1) ; P < 0.03), but IGFBP-3 did not differ. Cord IGF-I was positively correlated with all birth size measures except length, and most strongly with neonatal sum-of-skin-folds (r = 0.50, P < 0.001). IGFBP-3 was positively correlated with ponderal index, sum-of-skin-folds and placenta weight (r = 0.21, 0.19, 0.16, respectively; P < 0.05). Of maternal demographic and anthropometric characteristics, only parity was correlated with cord IGF-I (r = 0.27, P < 0.001). Among dietary behaviours, maternal daily milk intake at 34 weeks gestation predicted higher cord IGF-I compared to no-milk intake (51.8 ng mL(-1) vs. 36.5 ng mL(-1) , P < 0.01) after controlling for maternal characteristics, placental weight, and newborn gestational age, sex, weight and sum-of-skin-folds. Sum-of-skin-folds were positively associated with cord IGF-I in this multivariate model (57.3 ng mL(-1) vs. 35.1 ng mL(-1) for highest and lowest sum-of skin-fold quartile, P < 0.001). IGFBP-3 did not show significant relationships with these covariates.
In this Indian study, cord IGF-I concentration was associated with greater adiposity among newborns. Maternal milk intake may play a role in this relationship.
与欧洲婴儿相比，印度新生儿被描述为“瘦胖子”，但对于这种表型如何与胎儿生长因子胰岛素样生长因子I（IGF-I）或其结合蛋白IGFBP-3相关联，人们知之甚少。
评估一组印度新生儿脐带血中IGF-I和IGFBP-3的浓度，并评估它们与新生儿肥胖及母亲因素之间的关联。
一项前瞻性队列研究，对146名孕妇在妊娠28周和34周时进行饮食、人体测量和生化指标测量。在新生儿出生时测量其体重、身长、皮褶厚度、周长以及脐带血IGF-I和IGFBP-3的浓度。
脐带血中IGF-I和IGFBP-3的平均浓度分别为46.6（2.2）和1269.4（41）ng/mL。女孩的平均IGF-I水平高于男孩（51.4 ng/mL对42.9 ng/mL；P<0.03），但IGFBP-3水平无差异。脐带血IGF-I与除身长外的所有出生尺寸指标均呈正相关，与新生儿皮褶厚度总和的相关性最强（r = 0.50，P<0.001）。IGFBP-3与 ponderal指数、皮褶厚度总和及胎盘重量呈正相关（r分别为0.21、0.19、0.16；P<0.05）。在母亲的人口统计学和人体测量学特征中，只有产次与脐带血IGF-I相关（r = 0.27，P<0.001）。在饮食行为方面，在控制了母亲特征、胎盘重量以及新生儿胎龄、性别、体重和皮褶厚度总和后，妊娠34周时母亲每日的牛奶摄入量与较高的脐带血IGF-I相关（51.8 ng/mL对无牛奶摄入时的36.5 ng/mL，P<0.01）。在这个多变量模型中，皮褶厚度总和与脐带血IGF-I呈正相关（皮褶厚度总和最高和最低四分位数时分别为57.3 ng/mL对35.1 ng/mL，P<0.001）。IGFBP-3与这些协变量无显著关系。
在这项印度研究中，脐带血IGF-I浓度与新生儿更高的肥胖程度相关。母亲的牛奶摄入量可能在这种关系中起作用。
