印度新生儿脐带血胰岛素样生长因子-I浓度：与新生儿身体组成及母体决定因素的关联

Cord IGF-I concentrations in Indian newborns: associations with neonatal body composition and maternal determinants.

作者信息

Wiley A S, Lubree H G, Joshi S M, Bhat D S, Ramdas L V, Rao A S, Thuse N V, Deshpande V U, Yajnik C S

机构信息

Anthropology Department and Human Biology Program, Indiana University, Bloomington, IN, USA.

Kamalanayan Bajaj Diabetology Research Centre, KEM Hospital Research Centre, KEM Hospital, Pune, Maharashtra, India.

出版信息

Pediatr Obes. 2016 Apr;11(2):151-7. doi: 10.1111/ijpo.12038. Epub 2015 May 8.

DOI:10.1111/ijpo.12038

PMID:25955285

Abstract

BACKGROUND

Indian newborns have been described as 'thin-fat' compared with European babies, but little is known about how this phenotype relates to the foetal growth factor IGF-I (insulin-like growth factor I) or its binding protein IGFBP-3.

OBJECTIVE

To assess cord IGF-I and IGFBP-3 concentrations in a sample of Indian newborns and evaluate their associations with neonatal adiposity and maternal factors.

METHODS

A prospective cohort study of 146 pregnant mothers with dietary, anthropometric and biochemical measurements at 28 and 34 weeks gestation. Neonatal weight, length, skin-folds, circumferences, and cord blood IGF-I and IGFBP-3 concentrations were measured at birth.

RESULTS

Average cord IGF-I and IGFBP-3 concentrations were 46.6 (2.2) and 1269.4 (41) ng mL(-1) , respectively. Girls had higher mean IGF-I than boys (51.4 ng mL(-1) vs. 42.9 ng mL(-1) ; P < 0.03), but IGFBP-3 did not differ. Cord IGF-I was positively correlated with all birth size measures except length, and most strongly with neonatal sum-of-skin-folds (r = 0.50, P < 0.001). IGFBP-3 was positively correlated with ponderal index, sum-of-skin-folds and placenta weight (r = 0.21, 0.19, 0.16, respectively; P < 0.05). Of maternal demographic and anthropometric characteristics, only parity was correlated with cord IGF-I (r = 0.27, P < 0.001). Among dietary behaviours, maternal daily milk intake at 34 weeks gestation predicted higher cord IGF-I compared to no-milk intake (51.8 ng mL(-1) vs. 36.5 ng mL(-1) , P < 0.01) after controlling for maternal characteristics, placental weight, and newborn gestational age, sex, weight and sum-of-skin-folds. Sum-of-skin-folds were positively associated with cord IGF-I in this multivariate model (57.3 ng mL(-1) vs. 35.1 ng mL(-1) for highest and lowest sum-of skin-fold quartile, P < 0.001). IGFBP-3 did not show significant relationships with these covariates.

CONCLUSION

In this Indian study, cord IGF-I concentration was associated with greater adiposity among newborns. Maternal milk intake may play a role in this relationship.

摘要

背景

与欧洲婴儿相比，印度新生儿被描述为“瘦胖子”，但对于这种表型如何与胎儿生长因子胰岛素样生长因子I（IGF-I）或其结合蛋白IGFBP-3相关联，人们知之甚少。

目的

评估一组印度新生儿脐带血中IGF-I和IGFBP-3的浓度，并评估它们与新生儿肥胖及母亲因素之间的关联。

方法

一项前瞻性队列研究，对146名孕妇在妊娠28周和34周时进行饮食、人体测量和生化指标测量。在新生儿出生时测量其体重、身长、皮褶厚度、周长以及脐带血IGF-I和IGFBP-3的浓度。

结果

脐带血中IGF-I和IGFBP-3的平均浓度分别为46.6（2.2）和1269.4（41）ng/mL。女孩的平均IGF-I水平高于男孩（51.4 ng/mL对42.9 ng/mL；P<0.03），但IGFBP-3水平无差异。脐带血IGF-I与除身长外的所有出生尺寸指标均呈正相关，与新生儿皮褶厚度总和的相关性最强（r = 0.50，P<0.001）。IGFBP-3与 ponderal指数、皮褶厚度总和及胎盘重量呈正相关（r分别为0.21、0.19、0.16；P<0.05）。在母亲的人口统计学和人体测量学特征中，只有产次与脐带血IGF-I相关（r = 0.27，P<0.001）。在饮食行为方面，在控制了母亲特征、胎盘重量以及新生儿胎龄、性别、体重和皮褶厚度总和后，妊娠34周时母亲每日的牛奶摄入量与较高的脐带血IGF-I相关（51.8 ng/mL对无牛奶摄入时的36.5 ng/mL，P<0.01）。在这个多变量模型中，皮褶厚度总和与脐带血IGF-I呈正相关（皮褶厚度总和最高和最低四分位数时分别为57.3 ng/mL对35.1 ng/mL，P<0.001）。IGFBP-3与这些协变量无显著关系。