TMB - 8对离体兔主动脉中α - 肾上腺素能受体激动剂和氯化钾诱导收缩的影响。
Effect of TMB-8 on alpha-adrenoceptor agonist and KC1 induced-contractions in isolated rabbit aorta.
作者信息
Aleixandre M A, King A P, Puerro M
机构信息
Departamento de Farmacología, Facultad de Medicina, Universidad Complutense, Madrid, Spain.
出版信息
Gen Pharmacol. 1993 Jul;24(4):921-8. doi: 10.1016/0306-3623(93)90170-3.
PMID:7693542
Abstract
- TMB-8 (10(-6) M-10(-4) M) depresses the contractile effect of the selective alpha 1-adrenoceptor agonists methoxamine and phenylephrine in the isolated rabbit aorta. 2. TMB-8 also depresses contractions evoked by 80 mM KCl in this tissue when used at similar concentrations. 3. The calcium antagonist nifedipine potentiates the inhibitory effect of TMB-8 on the alpha 1-contractions. 4. In preparations mounted in Ca-free solution containing 0.5 mM EGTA, 10(-4) M TMB-8 markedly depressed the contractions caused by both alpha 1-adrenoceptor agonists. 5. The Ca2+ agonist BAY K 8644 (10(-6) M) partially prevented the inhibitory effect of TMB-8 on 80 mM KCl contractions.
摘要
- TMB - 8（10⁻⁶M - 10⁻⁴M）可抑制离体兔主动脉中选择性α₁ - 肾上腺素能受体激动剂甲氧明和去氧肾上腺素的收缩作用。2. 当以相似浓度使用时，TMB - 8也可抑制该组织中由80 mM氯化钾诱发的收缩。3. 钙拮抗剂硝苯地平可增强TMB - 8对α₁收缩的抑制作用。4. 在含有0.5 mM乙二醇双四乙酸（EGTA）的无钙溶液中制备的标本中，10⁻⁴M TMB - 8可显著抑制α₁ - 肾上腺素能受体激动剂引起的收缩。5. Ca²⁺激动剂BAY K 8644（10⁻⁶M）可部分阻止TMB - 8对80 mM氯化钾收缩的抑制作用。
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