脊髓腺苷调节辣椒素诱导的降压反射：腺苷A2受体的作用

Spinal adenosine modulates capsaicin-induced depressor reflex: involvement of adenosine A2 receptor.

Yang J M, Wu S N, Chen I J

Department of Pharmacology, Kaohsiung Medical College, Taiwan, R.O.C.

Gen Pharmacol. 1993 Jul;24(4):961-70. doi: 10.1016/0306-3623(93)90174-v.

Abstract

The depressor responses to i.a. and i.v. injection of capsaicin (CAP) were blocked following intrathecal (i.t.) perfusion of [D-Pro2, D-Trp7,9] substance P, a specific substance P antagonist. This confirmed that the CAP-elicited depressor reflex is mediated by substance P-containing afferent fibres. 2. The regulatory roles of spinal adenosine in the CAP-evoked substance P release and the possible involvement of adenosine A2 receptors were analyzed by analyzing the changes in cardiovascular responses to i.a. and i.v. injection of CAP after various pretreatments with adenosine agonists and antagonists, administered subcutaneously or intrathecally.

摘要

在鞘内（i.t.）灌注特异性P物质拮抗剂[D-脯氨酸2，D-色氨酸7，9]P物质后，对腹腔内（i.a.）和静脉内（i.v.）注射辣椒素（CAP）的降压反应被阻断。这证实了CAP诱发的降压反射是由含P物质的传入纤维介导的。2. 通过分析在用腺苷激动剂和拮抗剂进行各种预处理后，对腹腔内和静脉内注射CAP的心血管反应变化，来分析脊髓腺苷在CAP诱发的P物质释放中的调节作用以及腺苷A2受体的可能参与，这些预处理通过皮下或鞘内给药。