Thompson D, Whicher J T, Evans S W
Department of Clinical Medicine, Old Medical School, University of Leeds, United Kingdom.
Immunopharmacol Immunotoxicol. 1993 Aug;15(4):371-86. doi: 10.3109/08923979309035234.
Interleukin 6 is an important peptide regulatory factor with diverse biological activities including stimulation of acute phase protein synthesis. In this report we describe the effect of signal transduction pathway modulators on interleukin 6 mediated acute phase protein synthesis in a human hepatoma cell line Hep G2. Genistein, a tyrosine kinase inhibitor inhibited the interleukin 6 stimulated synthesis of acute phase proteins suggesting that a tyrosine kinase event participates in the signal transduction pathway. There was no evidence to suggest that protein kinase C had a stimulatory role although this or a related kinase may be involved in down-regulating the interleukin 6 signal.
白细胞介素6是一种重要的肽调节因子，具有多种生物学活性，包括刺激急性期蛋白合成。在本报告中，我们描述了信号转导通路调节剂对人肝癌细胞系Hep G2中白细胞介素6介导的急性期蛋白合成的影响。酪氨酸激酶抑制剂染料木黄酮抑制了白细胞介素6刺激的急性期蛋白合成，这表明酪氨酸激酶事件参与了信号转导通路。没有证据表明蛋白激酶C具有刺激作用，尽管这种或相关激酶可能参与下调白细胞介素6信号。
