Hayatsu H, Negishi T, Arimoto S, Hayatsu T
Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Mutat Res. 1993 Nov;290(1):79-85. doi: 10.1016/0027-5107(93)90035-e.
Studies have shown that there are many substances that can interfere with the actions of carcinogens and mutagens. Porphyrins, which often are constituents of diet, are a class of such inhibitors. Hemin can inhibit selectively the activity of mutagens having polycyclic structures by forming complexes with them. These effects were found with the use of bacterial assays and also by in vitro chemical experiments. A survey of porphyrins for similar effects has been done in our laboratory and it was found that chlorophyll and chlorophyllin act like hemin. These green pigments are antimutagenic in Salmonella and in Drosophila. Work from other laboratories also has supported the antimutagenic character of chlorophyllin. The possibility of modifying human exposure to carcinogens by use of these porphyrins is discussed. A porphyrin-like molecule, copper phthalocyanine trisulfonate, has been shown to have strong affinity to polycyclic compounds. Blue cotton, a cotton preparation bearing this blue pigment as a covalently bound ligand, has been demonstrated to be an adsorbent useful for isolating heterocyclic amines from food and other materials.
研究表明，有许多物质能够干扰致癌物和诱变剂的作用。卟啉通常是饮食的组成成分，是这类抑制剂中的一种。血红素能够通过与具有多环结构的诱变剂形成复合物，从而选择性地抑制其活性。这些效应通过细菌检测以及体外化学实验得以发现。我们实验室已针对卟啉的类似效应展开了一项调查，结果发现叶绿素和叶绿酸铁的作用与血红素相似。这些绿色色素在沙门氏菌和果蝇中具有抗诱变作用。其他实验室的研究也证实了叶绿酸铁的抗诱变特性。本文讨论了利用这些卟啉改变人类接触致癌物情况的可能性。一种类似卟啉的分子，即铜酞菁三磺酸盐，已被证明对多环化合物具有很强的亲和力。蓝色棉是一种含有这种蓝色色素作为共价结合配体的棉制品，已被证明是一种可用于从食物和其他材料中分离杂环胺的吸附剂。
