Yamanouchi H, Takashima S, Becker L E
Department of Pediatrics, Gunma University School of Medicine, Japan.
Neuropediatrics. 1993 Aug;24(4):200-3. doi: 10.1055/s-2008-1071539.
Substance P is a neuropeptide localized to selected neurons some of which may be involved in respiratory regulation. Substance P appears to be increased in the brainstem under conditions of hypoxia. A quantitative analysis of immunoreactivity to glial fibrillary acidic protein and substance P in the pons of 20 SIDS victims showed astroglial proliferation in the reticular formation and pontine nuclei and an increase of substance P in trigeminal fibers compared with age-matched controls. These observations suggest that in SIDS the neurons in the vicinity of the astrogliosis may be altered as indicated by the apparent increased expression of substance P, although the functional significance of this change on respiratory control is undetermined.
P物质是一种定位在特定神经元的神经肽，其中一些神经元可能参与呼吸调节。在缺氧条件下，脑干中的P物质似乎会增加。对20名婴儿猝死综合征（SIDS）受害者脑桥中胶质纤维酸性蛋白和P物质的免疫反应性进行定量分析，结果显示，与年龄匹配的对照组相比，网状结构和脑桥核中的星形胶质细胞增生，三叉神经纤维中的P物质增加。这些观察结果表明，在SIDS中，星形胶质细胞增生附近的神经元可能发生了改变，这表现为P物质表达明显增加，尽管这种变化对呼吸控制的功能意义尚未确定。
