Obonai T, Takashima S, Becker L E, Asanuma M, Mizuta R, Horie H, Tanaka J
Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, Tokyo, Japan.
Pediatr Neurol. 1996 Oct;15(3):189-92. doi: 10.1016/s0887-8994(96)00217-2.
Substance P and glial fibrillary acidic protein (GFAP) immunohistochemistry was applied to the medulla of neonatal infants who died of sudden infant death syndrome (SIDS). A quantitative analysis of cells demonstrating immunoreactivity to GFAP and substance P in 15 neonatal SIDS cases revealed increased GFAP immunoreactivity in the reticular formation, the dorsal vagal nucleus, and the solitary nucleus and an increase in substance P immunoreactivity in the spinal trigeminal nucleus and the solitary nucleus as compared with that in age-matched controls. GFAP immunopositivity suggests astrogliosis which implies a pathologic insult to neurons in the area of astrogliosis. The failure of neurons in these sites to show enhanced substance P immunopositivity may indirectly indicate altered neurons. Further study of prenatal events may be of importance in clarifying the pathogenesis of neonatal SIDS.
对死于婴儿猝死综合征（SIDS）的新生儿延髓进行了P物质和胶质纤维酸性蛋白（GFAP）免疫组织化学检测。对15例新生儿SIDS病例中显示对GFAP和P物质免疫反应性的细胞进行定量分析，结果显示，与年龄匹配的对照组相比，网状结构、迷走神经背核和孤束核中的GFAP免疫反应性增加，三叉神经脊束核和孤束核中的P物质免疫反应性增加。GFAP免疫阳性提示星形胶质细胞增生，这意味着星形胶质细胞增生区域的神经元受到了病理性损伤。这些部位的神经元未能显示出增强的P物质免疫阳性，可能间接表明神经元发生了改变。进一步研究产前事件可能对阐明新生儿SIDS的发病机制具有重要意义。
