Humpel C, Saria A
Department of Psychiatry, University Hospital, Innsbruck, Austria.
Neurosci Lett. 1993 Jul 23;157(2):223-6. doi: 10.1016/0304-3940(93)90742-4.
Tachykinins are highly concentrated in striatum and substantia nigra. Intranigral injection of selective neurokinin-1 and neurokinin-3 but not neurokinin-2 receptor agonists significantly decreased striatal dopamine metabolism at early time points (1 and 5 min) but increased dopamine metabolism at late time points (60 and 180 min). This probably modified striatal dopamine release, was, however, not able to influence striatal preprotachykinin-A gene expression. The data suggest that tachykinins modulate nigro-striatal dopamine neurons via neurokinin-1 and neurokinin-3 receptors and the modified dopamine stimulus is not strong enough to influence striatal tachykinin neurons.
速激肽在纹状体和黑质中高度集中。向黑质内注射选择性神经激肽-1和神经激肽-3（而非神经激肽-2）受体激动剂，在早期时间点（1分钟和5分钟）可显著降低纹状体多巴胺代谢，但在晚期时间点（60分钟和180分钟）会增加多巴胺代谢。这可能改变了纹状体多巴胺释放，然而，却无法影响纹状体前速激肽原-A基因表达。数据表明，速激肽通过神经激肽-1和神经激肽-3受体调节黑质-纹状体多巴胺神经元，且改变后的多巴胺刺激强度不足以影响纹状体速激肽神经元。
