Kes P, Reiner Z, Filjak K
Department of Internal Medicine, Sestre milosrdnice University Hospital, Zagreb, Croatia.
Ren Physiol Biochem. 1993 Sep-Oct;16(5):268-75. doi: 10.1159/000173772.
The influences of renal function and mass on the catabolism of serum gastrin were studied in 27 patients with hypertension caused by unilateral parenchymal renal disease (77.8%), renal artery stenosis (11.1%) and essential hypertension (11.1%). Blood for gastrin analysis was taken by catheterization from the aorta, inferior vena cava, renal veins and cubital vein. Separate renal functions were measured using radioisotope methods and the renal mass was also calculated. Significant differences (p < 0.001) in serum gastrin concentration between the aorta (29.5 +/- 6.7 pmol/l), inferior vena cava (23.4 +/- 5.8 pmol/l) and cubital vein (19.4 +/- 4.5 pmol/l) were found. Extrarenal gastrin extraction amounted to 12.5% and was considerably lower than renal gastrin extraction (20.5%). There was a significant positive correlation between renal gastrin extraction and renal blood flow or renal functional mass. Kidneys have an important, but not exclusive, role in the catabolism of endogenous gastrin in humans. In the catabolism of some, or at least some molecular forms of, gastrin, the capillary systems of extrarenal tissues have an important role.
在27例由单侧实质性肾病（77.8%）、肾动脉狭窄（11.1%）和原发性高血压（11.1%）引起的高血压患者中，研究了肾功能和肾质量对血清胃泌素分解代谢的影响。通过导管从主动脉、下腔静脉、肾静脉和肘静脉采集用于胃泌素分析的血液。使用放射性同位素方法测量各侧肾功能，并计算肾质量。发现主动脉（29.5±6.7 pmol/l）、下腔静脉（23.4±5.8 pmol/l）和肘静脉（19.4±4.5 pmol/l）之间血清胃泌素浓度存在显著差异（p<0.001）。肾外胃泌素提取率为12.5%，明显低于肾胃泌素提取率（20.5%）。肾胃泌素提取与肾血流量或肾功能质量之间存在显著正相关。肾脏在人体内源性胃泌素的分解代谢中起重要但非唯一的作用。在某些胃泌素或至少某些分子形式的胃泌素的分解代谢中，肾外组织的毛细血管系统起重要作用。
