McLain R F, Weinstein J N
Department of Orthopaedic Surgery, University of California, Davis, Sacramento.
Spine (Phila Pa 1976). 1993 Oct 1;18(13):1746-52. doi: 10.1097/00007632-199310000-00005.
The rabbit dorsal root ganglion is an important model of pain mechanisms in the human spine. A morphometric model of the normal rabbit dorsal root ganglion was constructed to provide quantitative comparisons with injured ganglia. Lumbar ganglia were studied under light and electron microscopy using simple stereologic methods. Neuronal diameter ranged from 18 to 85 microns, with 60% between 30 and 50 microns. Neurons constituted approximately 30% of dorsal root ganglion volume, and neuronal nuclei accounted for 14% of neuronal volume and 4% of dorsal root ganglion volume. Contributions from organelles to dorsal root ganglion volume were: mitochondria, 1.5%; rough endoplasmic reticulum, 9.4%; lysosomes, 0.2%; golgi, 0.5%. This morphometric model facilitates quantitative analysis of ganglia exposed to direct or indirect stimuli, providing important information on the structural changes that influence pain production.
兔背根神经节是人类脊柱疼痛机制的重要模型。构建了正常兔背根神经节的形态计量学模型，以便与损伤的神经节进行定量比较。使用简单的体视学方法在光镜和电镜下研究腰神经节。神经元直径范围为18至85微米，60%在30至50微米之间。神经元约占背根神经节体积的30%，神经元细胞核占神经元体积的14%和背根神经节体积的4%。细胞器对背根神经节体积的贡献为：线粒体1.5%；粗面内质网9.4%；溶酶体0.2%；高尔基体0.5%。这种形态计量学模型有助于对受到直接或间接刺激的神经节进行定量分析，为影响疼痛产生的结构变化提供重要信息。
