Kruszewski J, Raczka A
Department of Infectious Diseases, Central Clinical Hospital, Military School of Medicine, Warsaw, Poland.
Arch Immunol Ther Exp (Warsz). 1993;41(2):115-9.
Serum levels of total IgE, allergen-specific IgE (asIgE) and allergen-specific IgG-4 (asIgG-4) were measured in 194 patients in whom atopic disease of respiratory tract was suspected. The patients were divided into 8 groups based on the results of skin testing and sera levels of IgE and asIgE. Increase of the serum asIgG-4 level was observed in only 26 cases (13%), and occurred exclusively in patients with positive skin reactions to allergen(s) accompanied by increased serum levels of asIgE. In contrast, no significant elevation of serum asIgG-4 was found in non-atopic patients and in patients in whom skin testing and serologic evaluation did not yield conclusive results. These results argue against involvement of asIgG-4 antibodies in the pathogenesis of atopic diseases and against their function as sensitizer of target cell, analogous to the function of asIgE. In the present study elevated level of serum asIgG-4 was noted predominantly in asthmatic patients previously subjected to specific desensitization, that is to repeated exposure to antigen (allergen), which could induce specific antibody response. It is in agreement with the notion, that the appearance of asIgG-4 antibodies in sera of the patients under study is a consequence of the specific immunization, and not of atopy.
对194例疑似患有呼吸道过敏性疾病的患者测定了血清总IgE、过敏原特异性IgE（asIgE）和过敏原特异性IgG-4（asIgG-4）水平。根据皮肤试验结果以及IgE和asIgE的血清水平，将患者分为8组。仅在26例（13%）患者中观察到血清asIgG-4水平升高，且仅发生在对过敏原皮肤反应呈阳性且血清asIgE水平升高的患者中。相比之下，在非过敏性患者以及皮肤试验和血清学评估未得出明确结果的患者中，未发现血清asIgG-4有显著升高。这些结果表明，asIgG-4抗体不参与过敏性疾病的发病机制，也不具有类似于asIgE的作为靶细胞致敏剂的功能。在本研究中，血清asIgG-4水平升高主要见于先前接受过特异性脱敏治疗的哮喘患者，即反复接触抗原（过敏原），这可能诱导特异性抗体反应。这与以下观点一致，即研究中患者血清中asIgG-4抗体的出现是特异性免疫的结果，而非特应性的结果。
