Kruszewski J, Raczka A, Kłos M, Wiktor-Jedrzejczak W
Department of Infectious Diseases, Central Clinical Hospital, Military School of Medicine, Warsaw, Poland.
Arch Immunol Ther Exp (Warsz). 1994;42(4):259-61.
High serum levels of asIgG-4 against common food allergens are found in many patients with symptoms suggesting food allergy. The same patients are frequently negative for allergen specific IgE (asIgE) against the same allergens. These data were frequently interpreted as suggestive of a role of asIgG-4 in food allergy. In order to evaluate this hypothesis we tested serum levels of asIgG-4 against food allergens in young blood donors without any signs or history of food allergy. Fifty young healthy male donors were evaluated. The serum levels of IgE, and asIgE and IgG-4 against 14 common food allergens were determined. The studies were carried out using commercially available 3M Diagnostics Systems kits. AsIgG-4 against food allergens were found in sera of 92% blood donors, and in 62% of these healthy persons the levels of asIgG-4 were higher than 10.0 micrograms/ml. In a small proportion of patients, high serum levels of IgE and asIgE against the same food and/or inhalant allergens were found. Common occurrence of asIgG-4 against food allergens in healthy persons (without any symptoms which could suggest allergy or food intolerance) argues against the possible participation of these antibodies in the pathogenesis of food allergy. It is possible that their occurrence is the result of immunization against food antigens (allergens). It remains to be resolved whether the presence of these antibodies represents an epiphenomenon or may have some other biological role.
许多有食物过敏症状的患者血清中抗常见食物过敏原的IgG-4水平较高。这些患者针对相同过敏原的过敏原特异性IgE（sIgE）检测结果通常为阴性。这些数据常被解读为提示IgG-4在食物过敏中发挥作用。为了评估这一假设，我们检测了无任何食物过敏体征或病史的年轻献血者血清中抗食物过敏原的IgG-4水平。对50名年轻健康男性献血者进行了评估。测定了他们血清中针对14种常见食物过敏原的IgE、sIgE和IgG-4水平。研究使用市售的3M诊断系统试剂盒进行。92%的献血者血清中检测到抗食物过敏原的IgG-4，其中62%的健康人IgG-4水平高于10.0微克/毫升。在一小部分患者中，发现针对相同食物和/或吸入性过敏原的血清IgE和sIgE水平较高。健康人（无任何提示过敏或食物不耐受症状）中普遍存在抗食物过敏原的IgG-4，这表明这些抗体不太可能参与食物过敏的发病机制。它们的出现可能是食物抗原（过敏原）免疫的结果。这些抗体的存在是一种附带现象还是可能具有其他生物学作用，仍有待解决。
