Saleh A A, Ozawa T, Isada N B, Johnson M P, Dombrowski M P, Evans M I, Treadwell M B, Mammen E F
Department of Obstetrics and Gynecology, Hutzel Hospital, Wayne State University, Detroit, Mich.
Fetal Diagn Ther. 1993 May-Jun;8(3):175-7. doi: 10.1159/000263820.
Platelet factor 4 (PF4) and beta-thromboglobulin (BTG) are unique markers of irreversible platelet activation. We measured PF4 and BTG in amniotic fluid from 102 genetic amniocenteses, in which 78 had normal amniotic fluid alpha-fetoprotein (AFP) levels with normal pregnancies, and 24 had high amniotic fluid AFP levels with abnormal pregnancies. PF4 and BTG were significantly higher in the abnormal pregnancy/elevated amniotic fluid AFP group (p < 0.002 in each case) and correlated with AFP expressed as multiples of the median (p < 0.05 and p < 0.0001, respectively). Our results are compatible with passage of PF4 and BTG across fetal membranes and/or enhanced fetal platelet activation in fetuses with structural anomalies and elevated AFP.
血小板第4因子（PF4）和β-血小板球蛋白（BTG）是不可逆血小板活化的独特标志物。我们检测了102例遗传羊膜腔穿刺术羊水样本中的PF4和BTG，其中78例羊水甲胎蛋白（AFP）水平正常且妊娠正常，24例羊水AFP水平升高且妊娠异常。在妊娠异常/羊水AFP升高组中，PF4和BTG显著更高（每种情况p < 0.002），并且与以中位数倍数表示的AFP相关（分别为p < 0.05和p < 0.0001）。我们的结果与PF4和BTG穿过胎膜和/或结构异常及AFP升高胎儿的胎儿血小板活化增强相一致。
