White D J
Department of Surgery, University of Cambridge, England, UK.
Br J Biomed Sci. 1993 Sep;50(3):277-83.
Clinical orthotopic heart transplantation has been one of the most spectacular medical success stories of the last quarter of the 20th century. This review describes briefly the history of the development of the immunosuppressive protocols that were responsible for this success, together with details of current immunosuppressive regimens, including both advantages and disadvantages of the various approaches used in different heart transplant centres. Special reference is made to the use of monoclonal antibodies and the newly-discovered immunosuppressive reagent FK 506.
临床原位心脏移植一直是20世纪最后25年中最引人注目的医学成功案例之一。本综述简要描述了促成这一成功的免疫抑制方案的发展历程，以及当前免疫抑制方案的详细情况，包括不同心脏移植中心所采用的各种方法的优缺点。特别提到了单克隆抗体的使用以及新发现的免疫抑制试剂FK 506。
