Björnsson E, Janson C, Håkansson L, Enander I, Venge P, Boman G
Department of Lung Medicine and Asthma Research Center, Akademiska sjukhuset, Uppsala, Sweden.
Allergy. 1994 Oct;49(9):730-6. doi: 10.1111/j.1398-9995.1994.tb02095.x.
How are the serum concentration of eosinophil cationic protein (S-ECP) and the blood eosinophil count (B-Eos) related to symptoms of asthma, allergy, and bronchial hyperresponsiveness (BHR)? We measured S-ECP, B-Eos, and total and specific IgE in serum in blood samples from 699 randomly selected persons 20-44 years old. They also underwent a structured interview, spirometry, a methacholine provocation test, and skin prick tests as part of the European Community Respiratory Health Survey. B-Eos and S-ECP were found to be closely related to asthma symptom score (P < 0.001), total IgE (P < 0.001), and BHR (P < 0.001). On the basis of the results, the subjects were divided into four groups: healthy controls, patients with allergic rhinitis, patients with nonallergic asthma, and patients with allergic asthma. There were significant differences in both B-Eos and S-ECP among the groups (P < 0.001), the highest values being found in the allergic asthma group. B-Eos and S-ECP each had an additive value in predicting the occurrence of asthma. Among persons with high concentrations of both variables, asthma was eight times more common than in those with low concentrations. Allergy and BHR were also found to be independently related to B-Eos and S-ECP levels. Furthermore, both B-Eos and S-ECP showed good correlation to subjective and objective measures of asthma activity. We conclude that both B-Eos and S-ECP and their interrelationship may be of value in assessing the activity of asthma. However, their role in disease management was not established in this cross-sectional study.
嗜酸性粒细胞阳离子蛋白血清浓度（S-ECP）和血液嗜酸性粒细胞计数（B-Eos）与哮喘、过敏及支气管高反应性（BHR）症状有何关联？我们对699名年龄在20至44岁之间随机选取的人员的血液样本进行检测，测定其血清中的S-ECP、B-Eos、总IgE及特异性IgE。作为欧洲共同体呼吸健康调查的一部分，他们还接受了结构化访谈、肺功能测定、乙酰甲胆碱激发试验及皮肤点刺试验。结果发现，B-Eos和S-ECP与哮喘症状评分（P < 0.001）、总IgE（P < 0.001）及BHR（P < 0.001）密切相关。基于这些结果，受试者被分为四组：健康对照组、过敏性鼻炎患者、非过敏性哮喘患者及过敏性哮喘患者。各组间B-Eos和S-ECP均存在显著差异（P < 0.001），过敏性哮喘组的值最高。B-Eos和S-ECP在预测哮喘发生方面均具有附加价值。在这两个变量浓度均高的人群中，哮喘的发生率比浓度低的人群高八倍。还发现过敏和BHR与B-Eos和S-ECP水平独立相关。此外，B-Eos和S-ECP与哮喘活动的主观和客观指标均显示出良好的相关性。我们得出结论，B-Eos和S-ECP及其相互关系在评估哮喘活动中可能具有价值。然而，在这项横断面研究中未确定它们在疾病管理中的作用。
