200株对青霉素敏感和耐药的肺炎球菌对哌拉西林、哌拉西林-他唑巴坦、替卡西林、替卡西林-克拉维酸、氨苄西林、氨苄西林-舒巴坦、头孢他啶和头孢曲松的敏感性。
Susceptibilities of 200 penicillin-susceptible and -resistant pneumococci to piperacillin, piperacillin-tazobactam, ticarcillin, ticarcillin-clavulanate, ampicillin, ampicillin-sulbactam, ceftazidime, and ceftriaxone.
作者信息
Pankuch G A, Jacobs M R, Appelbaum P C
机构信息
Department of Pathology (Clinical Microbiology), Hershey Medical Center, Pennsylvania 17033.
出版信息
Antimicrob Agents Chemother. 1994 Dec;38(12):2905-7. doi: 10.1128/AAC.38.12.2905.
MICs of eight beta-lactams (piperacillin, piperacillin-tazobactam, ticarcillin, ticarcillin-clavulanate, ampicillin, ampicillin-sulbactam, ceftazidime, and ceftriaxone) were determined by agar dilution against 64 penicillin-susceptible, 70 intermediately penicillin-resistant, and 66 fully penicillin-resistant pneumococci. The MICs of piperacillin with and without tazobactam for 90% of the susceptible, intermediately resistant, and resistant strains tested (MIC90s) were < or = 0.064, 2.0, and 4.0 micrograms/ml, respectively. By comparison, those of ampicillin with and without sulbactam were 0.125, 2.0, and 4.0 micrograms/ml and those of ceftriaxone were < or = 0.064, 1.0, and 2.0 micrograms/ml, respectively. Strains were less susceptible to ticarcillin with and without clavulanate (MIC90s, 2.0, 64.0, and 128.0 micrograms/ml) and ceftazidime (MIC90s, 1.0, 8.0, and 32.0 micrograms/ml).
采用琼脂稀释法测定了8种β-内酰胺类抗生素（哌拉西林、哌拉西林-他唑巴坦、替卡西林、替卡西林-克拉维酸、氨苄西林、氨苄西林-舒巴坦、头孢他啶和头孢曲松）对64株青霉素敏感、70株中度青霉素耐药和66株完全青霉素耐药肺炎球菌的最低抑菌浓度（MIC）。哌拉西林单用及与他唑巴坦联用对90%受试敏感、中度耐药和耐药菌株的MIC90分别≤0.064、2.0和4.0微克/毫升。相比之下，氨苄西林单用及与舒巴坦联用的MIC90分别为0.125、2.0和4.0微克/毫升，头孢曲松的MIC90分别≤0.064、1.0和2.0微克/毫升。菌株对替卡西林单用及与克拉维酸联用（MIC90分别为2.0、64.0和128.0微克/毫升）以及头孢他啶（MIC90分别为1.0、8.0和32.0微克/毫升）的敏感性较低。
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