曲伐沙星，一种对肺炎链球菌具有强效活性的新型氟喹诺酮类药物。
Trovafloxacin, a new fluoroquinolone with potent activity against Streptococcus pneumoniae.
作者信息
Thomson K S, Chartrand S A, Sanders C C, Block S L
机构信息
Department of Medical Microbiology and Immunology, Creighton University, School of Medicine, Omaha, Nebraska 68178, USA.
出版信息
Antimicrob Agents Chemother. 1997 Feb;41(2):478-80. doi: 10.1128/AAC.41.2.478.
Abstract
An in vitro study of the activity of 15 antibacterial agents against 202 recent pediatric isolates of Streptococcus pneumoniae from urban and rural Nebraska and rural Kentucky identified trovafloxacin, ofloxacin, clindamycin, and vancomycin as the most active agents and equally active against both penicillin-susceptible and--resistant strains. In contrast, six beta-lactams, three macrolides, and trimethoprim-sulfamethoxazole were less active overall, especially against penicillin-intermediate and--resistant strains. Trovafloxacin inhibited all strains at a concentration of < or = 0.25 micrograms/ml and was 8- to 16-fold more potent than ofloxacin or ciprofloxacin.
摘要
一项针对来自内布拉斯加州城乡以及肯塔基州农村地区的202株近期儿科肺炎链球菌分离株，对15种抗菌剂活性的体外研究表明，曲伐沙星、氧氟沙星、克林霉素和万古霉素是活性最强的药物，对青霉素敏感和耐药菌株的活性相同。相比之下，六种β-内酰胺类药物、三种大环内酯类药物以及甲氧苄啶-磺胺甲恶唑总体活性较低，尤其是对青霉素中介和耐药菌株。曲伐沙星在浓度≤0.25微克/毫升时可抑制所有菌株，其效力比氧氟沙星或环丙沙星强8至16倍。
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