Brambilla E, Belluomo G, Malerba A, Buscaglia M, Strohmenger L
Department of Dentistry and Stomatology, University of Milan, School of Medicine, Italy.
Arch Oral Biol. 1994 Nov;39(11):991-4. doi: 10.1016/0003-9969(94)90084-1.
The aim was to measure the ionic fluoride concentration in maternal plasma and in amniotic fluid after oral administration of different doses of sodium fluoride (NaF) to 121 pregnant women. They were divided into six groups, according to the dose administered; 0 for the control group and 0.25, 0.50, 0.75, 1.00 or 1.25 mg of F- for the others. The subjects were instructed to take the corresponding NaF dose both 24 and 3 h before amniocentesis. Amniotic fluid (5 ml) and venous blood (5 ml) were obtained from each subject. Ionic fluoride concentration was measured with an expanded-scale potentiometer and a selective fluoride electrode. The results showed that F- concentration in amniotic fluid and, presumably, in fetal circulation, was not significantly different in groups taking 0.25, 0.50, 0.75 or 1.00 mg/day of F-. The F- concentration in amniotic fluid of the 1.25 mg/day group was, however, significantly higher than in all the other groups.
目的是在121名孕妇口服不同剂量的氟化钠（NaF）后，测量其母血和羊水中的离子氟浓度。根据给药剂量，她们被分为六组；对照组为0，其他组分别为0.25、0.50、0.75、1.00或1.25毫克氟离子。受试者被要求在羊膜穿刺术前24小时和3小时服用相应剂量的NaF。从每个受试者采集5毫升羊水和5毫升静脉血。使用扩展量程电位计和选择性氟电极测量离子氟浓度。结果显示，每日摄入0.25、0.50、0.75或1.00毫克氟离子的组，羊水中以及推测胎儿循环中的氟离子浓度无显著差异。然而，每日摄入1.25毫克组的羊水中氟离子浓度显著高于所有其他组。
