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肾移植后巨细胞病毒继发胃肠道出血。一例病例报告及问题综述。

Gastrointestinal hemorrhage secondary to cytomegalovirus after renal transplantation. A case report and review of the problem.

作者信息

Diethelm A G, Gore I, Ch'ien L T, Sterling W A, Morgan J M

出版信息

Am J Surg. 1976 Mar;131(3):371-4. doi: 10.1016/0002-9610(76)90136-7.

DOI:10.1016/0002-9610(76)90136-7
PMID:769586
Abstract

Generalized cytomegalovirus infection was associated with massive and ultimately fatal upper gastrointestinal bleeding in a renal allograft recepient and persisted even after subtotal gastric resection. The surgical specimen and the remaining stomach at autopsy revealed multiple superficial ulcerations with cytomegalic inclusion bodies within the gastric mucosa. Renal failure in the terminal stages of the patient's illness required hemodialysis but did not seem to be the sole result of allograft rejection, suggesting that the renal dysfunction may be caused by the systemic viral infection.

摘要

广泛性巨细胞病毒感染与一名肾移植受者严重且最终致命的上消化道出血相关,即便在胃次全切除术后仍持续存在。手术标本及尸检时剩余的胃显示胃黏膜有多个浅表溃疡,伴有巨细胞包涵体。患者疾病终末期的肾衰竭需要血液透析,但似乎并非移植肾排斥的唯一结果,这表明肾功能障碍可能由全身性病毒感染所致。

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1
Gastrointestinal hemorrhage secondary to cytomegalovirus after renal transplantation. A case report and review of the problem.肾移植后巨细胞病毒继发胃肠道出血。一例病例报告及问题综述。
Am J Surg. 1976 Mar;131(3):371-4. doi: 10.1016/0002-9610(76)90136-7.
2
[Solitary gastric ulcer due to cytomegalovirus: a cause of acute digestive hemorrhage].[巨细胞病毒所致孤立性胃溃疡:急性消化道出血的一个病因]
Rev Esp Enferm Dig. 1991 Jan;79(1):43-5.
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[The correlation of gastric secretory function and morphological changes in the gastric mucosa in peptic ulcer complicated by hemorrhage].[消化性溃疡合并出血时胃分泌功能与胃黏膜形态学改变的相关性]
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Hypercalcemia-induced upper gastrointestinal bleeding after renal transplantation.肾移植术后高钙血症所致上消化道出血
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引用本文的文献

1
The enhancer domain of the human cytomegalovirus major immediate-early promoter determines cell type-specific expression in transgenic mice.人类巨细胞病毒主要立即早期启动子的增强子结构域决定了转基因小鼠中的细胞类型特异性表达。
J Virol. 1996 May;70(5):3207-14. doi: 10.1128/JVI.70.5.3207-3214.1996.
2
Rash produced by mouse cytomegalovirus.由小鼠巨细胞病毒产生的皮疹。
Infect Immun. 1983 Jul;41(1):352-7. doi: 10.1128/iai.41.1.352-357.1983.
3
Cytomegalic inclusion disease diagnosed endoscopically.
Dig Dis Sci. 1981 Feb;26(2):133-5. doi: 10.1007/BF01312230.
4
Cytomegalovirus gastritis: protean radiologic features.巨细胞病毒性胃炎:多样的放射学特征
Gastrointest Radiol. 1992 Summer;17(3):202-6. doi: 10.1007/BF01888548.
5
Alimentary tract complications after renal transplantation.
Ann Surg. 1979 Oct;190(4):535-42. doi: 10.1097/00000658-197910000-00013.
6
Surgical management of complications of steroid therapy.类固醇疗法并发症的外科治疗
Ann Surg. 1977 Mar;185(3):251-63. doi: 10.1097/00000658-197703000-00001.