Klaase J M, Kroon B B, Eggermont A M, van Geel A N, Schraffordt Koops H, Oldhoff J, Liénard D, Lejeune F J, Berkel R, Franklin H R
Department of Surgery, The Netherlands Cancer Institute, Amsterdam.
Eur J Cancer. 1995;31A(1):58-63. doi: 10.1016/0959-8049(94)00372-c.
The aim of this study was to investigate the role of mild hyperthermia (39-40 degrees C) in isolated cytostatic perfusion for patients with recurrent melanoma of the extremities. A total of 218 patients treated with mild hyperthermic perfusion was compared to 166 patients perfused under controlled normothermic conditions (37-38 degrees C). Only patients whose lesions had been excised before or at the moment of perfusion were eligible for this study. A variety of prognostic factors was controlled for in a Cox proportional hazards analysis. The application of mild hyperthermia did not influence limb recurrence-free interval nor survival (corrected P values 0.46 and 0.18, respectively). In this retrospective comparative study, no benefit for mild hyperthermia in regional isolated perfusion could be identified.
本研究的目的是探讨轻度热疗（39 - 40摄氏度）在四肢复发性黑色素瘤患者的离体细胞毒性灌注中的作用。将总共218例接受轻度热灌注治疗的患者与166例在可控常温条件下（37 - 38摄氏度）进行灌注的患者进行比较。只有那些在灌注前或灌注时病变已被切除的患者才有资格参与本研究。在Cox比例风险分析中对多种预后因素进行了控制。轻度热疗的应用既不影响肢体无复发生存期，也不影响总生存期（校正P值分别为0.46和0.18）。在这项回顾性比较研究中，未发现轻度热疗在局部离体灌注中有任何益处。
