Connolly F M, Mirakhur R K, Loan P B, McCoy E P, Symington M, Kumar N
Department of Anaesthetics, Queen's University of Belfast.
Br J Anaesth. 1995 Feb;74(2):229-30. doi: 10.1093/bja/74.2.229.
Seventy adult patients received mivacurium 0.15 mg kg-1 during anaesthesia with thiopentone, nitrous oxide and 0.5% halothane. Neuromuscular block was monitored using mechanomyography and train-of-four stimulation. Edrophonium 0.75 mg kg-1 was administered 5 or 10 min after mivacurium, or when the first response in the TOF (T1) had recovered to 5, 10, 25 or 50% of control in groups of 10 patients each. A control group was allowed to recover spontaneously. The mean time taken from administration of mivacurium to attaining a TOF ratio of 0.7 was between 19.3 and 24.9 min in the groups given edrophonium, regardless of the time of administration, compared with 26.7 min in the spontaneous recovery group. The differences, however, were not significant among the groups showing little advantage in antagonizing mivacurium block.
70例成年患者在硫喷妥钠、氧化亚氮和0.5%氟烷麻醉期间接受了0.15 mg/kg米库氯铵。使用肌动描记法和四个成串刺激监测神经肌肉阻滞。在米库氯铵给药后5或10分钟，或者当四个成串刺激（T1）的第一个反应恢复到对照值的5%、10%、25%或50%时（每组10例患者），给予0.75 mg/kg依酚氯铵。对照组自然恢复。在给予依酚氯铵的组中，无论给药时间如何，从给予米库氯铵到四个成串刺激比值达到0.7的平均时间在19.3至24.9分钟之间，而自然恢复组为26.7分钟。然而，在拮抗米库氯铵阻滞方面，各给药组之间差异不显著，几乎没有优势。
