Finkelstein J W
Program in Biobehavioral Health, Pennsylvania State University, University Park 16802.
J Adolesc Health. 1994 Dec;15(8):612-8. doi: 10.1016/s1054-139x(94)90627-0.
Biological and behavioral change occurs throughout the lifespan. The nature and rapidity of change during adolescence is striking. The effects of rapid growth, sexual maturation, and psychological reorganization on pharmacodynamics and pharmacokinetics must be considered during studies on teenagers. It is important to consider the large amount of variability in the timing of normal developmental events. The concept of developmental rather than chronological age should be considered. Measurement of organismic and behavioral variables includes whole organism measures such as body height, weight, surface area, body mass index, self-concept, sexual identity/role, and many other behavioral measures. Pubertal development may be assessed by sexual maturity ratings. Bone age may be a particularly useful estimate of developmental status. Biochemical measures include gonadotropin, sex steroids, other hormonal or hormone receptor values.
生物和行为变化贯穿一生。青春期变化的性质和速度引人注目。在对青少年进行研究时，必须考虑快速生长、性成熟和心理重组对药效学和药代动力学的影响。重要的是要考虑正常发育事件时间安排上的大量变异性。应该考虑发育年龄而非实足年龄的概念。对机体和行为变量的测量包括对整个机体的测量，如身高、体重、表面积、体重指数、自我概念、性身份/角色以及许多其他行为测量。青春期发育可通过性成熟评级来评估。骨龄可能是发育状态的一个特别有用的估计指标。生化指标包括促性腺激素、性类固醇、其他激素或激素受体值。
