Tanaka M, Aze Y, Fujita T
Fukui Institute for Safety Research, ONO Pharmaceutical Co., Ltd., Japan.
J Vet Med Sci. 1994 Dec;56(6):1173-5. doi: 10.1292/jvms.56.1173.
Megakaryocytic emperipolesis was observed in the rat bone marrow when lipopolysaccharide (LPS) was administrated intravenously at a daily dose of 0.5 mg/kg body weight for 4 weeks. Emperipolesis was significantly increased in the LPS-treated group (3.54%) as compared with the control group (1.35%). Histologically, several types of hematocytes were engulfed within megakaryocytes, but the host cells and entering hematocytes showed no degenerative alterations. Morphologically, most megakaryocytes showing emperipolesis were classified into the mature type indicating high platelet producting ability but platelet counts in the peripheral blood were markedly reduced in the LPS-treated group (63.7 x 10(4)/mm3) as compared with the control group (128.4 x 10(4)/mm3). These results suggest that the emperipolesis is a phenomenon closely related to the marked reduction in the number of platelets and accelerated platelet production of megakaryocytes.
当以每日0.5毫克/千克体重的剂量静脉注射脂多糖（LPS），持续4周时，在大鼠骨髓中观察到巨核细胞吞噬现象。与对照组（1.35%）相比，LPS处理组的吞噬现象显著增加（3.54%）。组织学上，几种血细胞被巨核细胞吞噬，但宿主细胞和进入的血细胞未显示退行性改变。形态学上，大多数表现出吞噬现象的巨核细胞被归类为成熟型，表明血小板生成能力高，但与对照组（128.4×10⁴/mm³）相比，LPS处理组外周血中的血小板计数显著降低（63.7×10⁴/mm³）。这些结果表明，吞噬现象是一种与血小板数量显著减少以及巨核细胞加速血小板生成密切相关的现象。
