Block F, Pergande G, Schwarz M
Department of Neurology, University of Essen, Germany.
Neuroreport. 1994 Dec 20;5(18):2630-2. doi: 10.1097/00001756-199412000-00056.
The present study investigated whether flupirtine attenuates the depression and enhances the recovery of the b-wave of the electroretinogram (ERG) in response to retinal ischaemia. The ERG was recorded from pentobarbital-anaesthetized rats before, during and after transient (24 min) occlusion of both common carotid arteries. Flupirtine administered 20 min before ischaemia reduced the depression of the b-wave during occlusion and accelerated recovery during reperfusion. When given at the onset of ischaemia flupirtine led to attenuation of the reduction of the b-wave during occlusion and to enhancement of the recovery during reperfusion. The present results suggest that flupirtine provides protection against ischaemic retinal dysfunction.
